DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and ACKR4

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_057641.1	Gene:	ACKR4 / 51554	HGNCID:	1611	Length:	350	Species:	Homo sapiens

Alignment Length:	332	Identity:	87/332 - (26%)
Similarity:	152/332 - (45%)	Gaps:	40/332 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 QQNGSHYLEYDDDGPDCSYSYN------------FILKLITMILYALVCIIGLFGNTLVIYVVMR 172
            :||.|....|:::..:.:|.|:            ...|:...:...:|.:|||.||::|:.:...
Human     4 EQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAY 68

  Fly   173 FSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLI 237
            :.|.:|.|::||||||:||...|..:||.... .|..|..|..|||......::...:...||..
Human    69 YKKQRTKTDVYILNLAVADLLLLFTLPFWAVN-AVHGWVLGKIMCKITSALYTLNFVSGMQFLAC 132

  Fly   238 MSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDT 302
            :|.|||:||....|......|  ..::....||.::||.:|.::|.:.    |.|..|...:|..
Human   133 ISIDRYVAVTKVPSQSGVGKP--CWIICFCVWMAAILLSIPQLVFYTV----NDNARCIPIFPRY 191

  Fly   303 QNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVT---KLVLTV 364
            ..:...:...:..:.:||..|...:.|.|.:..|.|           .|..:.|::   |::|||
Human   192 LGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTL-----------MKMPNIKISRPLKVLLTV 245

  Fly   365 ISAYIFCWLPHWISQ----VALISSAPQRC--ASRLELAVFLACGCLSYSNSAMNPILYAFLSDN 423
            :..:|...||:.|.:    :.:|.|....|  :.|:::|:.:. ..::..:|.:|||||.|:..:
Human   246 VIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVT-ESIALFHSCLNPILYVFMGAS 309

  Fly   424 FKKSFMK 430
            ||...||
Human   310 FKNYVMK 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	60/218 (28%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	69/263 (26%)
ACKR4	NP_057641.1	7tmA_ACKR4_CCR11	42..314	CDD:320304	78/290 (27%)
		TM helix 1	42..69	CDD:320304	7/26 (27%)
		TM helix 2	76..101	CDD:320304	12/25 (48%)
		TM helix 3	112..142	CDD:320304	9/29 (31%)
		TM helix 4	152..174	CDD:320304	6/23 (26%)
		TM helix 5	197..226	CDD:320304	5/28 (18%)
		TM helix 6	233..263	CDD:320304	9/29 (31%)
		TM helix 7	282..307	CDD:320304	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910