DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and P2RY4

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_002556.1	Gene:	P2RY4 / 5030	HGNCID:	8542	Length:	365	Species:	Homo sapiens

Alignment Length:	309	Identity:	83/309 - (26%)
Similarity:	154/309 - (49%)	Gaps:	24/309 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 DCSYSYNFILKLITM-ILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGI 198
            ||.:..:|  |.|.: :.||:|.::||..|...:::.:...:....|..|:.:||::|..:::.:
Human    26 DCWFDEDF--KFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSL 88

  Fly   199 PFLLYTMQVGN-WPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSK 262
            |.|:|.....| ||||..:||..........:.|.:||..:|..||:.:|||:.:.|:..|.::.
Human    89 PTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAG 153

  Fly   263 LVSAFAWMTSVLLMLPVILFASTVQSSNG-NVSCNIEWPDTQNSHTDSTFILY-SLVLG--FATP 323
            |:....|:.....::|.:.|.:|  |:.| .|.|:    ||........::.: |.|:|  |..|
Human   154 LLCLAVWLVVAGCLVPNLFFVTT--SNKGTTVLCH----DTTRPEEFDHYVHFSSAVMGLLFGVP 212

  Fly   324 LTFILVFYCLVIRKLHTVGP-KHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQ----VALI 383
            ....||.|.|:.|:|:...| ..:|..:.||.|.:. :||||   :..|::|..|::    :|.:
Human   213 CLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIA-VVLTV---FAVCFVPFHITRTIYYLARL 273

  Fly   384 SSAPQRCASRLELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKAC 432
            ..|..|..:.:.: |:.....|:.:||.::|:||....|.:::...:.|
Human   274 LEADCRVLNIVNV-VYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLC 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	60/221 (27%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	69/264 (26%)
P2RY4	NP_002556.1	7tmA_P2Y4	36..317	CDD:320496	78/291 (27%)
		TM helix 1	36..63	CDD:320496	7/26 (27%)
		TM helix 2	70..95	CDD:320496	8/24 (33%)
		TM helix 3	108..138	CDD:320496	8/29 (28%)
		TM helix 4	150..172	CDD:320496	3/21 (14%)
		TM helix 5	197..226	CDD:320496	9/28 (32%)
		TM helix 6	238..268	CDD:320496	10/33 (30%)
		TM helix 7	285..310	CDD:320496	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910