Protein Alignment AstC-R2 and OPRD1

DIOPT Version :10

• Sequence 1: NP_001303398.1
• Gene: AstC-R2 / 40019
• FlyBaseID: FBgn0036789
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_000902.3
• Gene: OPRD1 / 4985
• HGNCID: 8153
• Length: 372
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 119/347 - (34%)
• Similarity: 190/347 - (54%)
• Gaps: 25/347 - (7%)

  Fly   134 PDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGI 198
            |....:.:..|.:....||:.||.:||.||.||::.::|::||:|.|||||.|||:||......:
Human    38 PGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTL 102

  Fly   199 PFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKL 263
            ||......:..||||..:|||.:.......|||...|.:||.|||||||||:.:..:|||..:||
Human   103 PFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKL 167

  Fly   264 VSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLVLGFATPLTFIL 328
            ::...|:.:..:.:|:::.|.| :..:|.|.|.:::| :.:.:.|:...:...:..|..|:..|.
Human   168 INICIWVLASGVGVPIMVMAVT-RPRDGAVVCMLQFP-SPSWYWDTVTKICVFLFAFVVPILIIT 230

  Fly   329 VFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLP-HWISQVALISSAPQRCAS 392
            |.|.|::.:|.:|.....||||.||.|::|::||.|:.|::.||.| |....|..:....:|  .
Human   231 VCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRR--D 293

  Fly   393 RLELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKAC--TCAARKDVNAQLQLENSFFPKFG 455
            .|.:|....|..|.|:||::||:|||||.:|||:.|.:.|  .| .|.|.::           |.
Human   294 PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPC-GRPDPSS-----------FS 346

  Fly   456 KGRQS---ERLLG---GNGKGG 471
            :.|::   ||:..   .:|.||
Human   347 RAREATARERVTACTPSDGPGG 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tmA_AstC_insect	146..428	CDD:320222	105/282 (37%)
		TM helix 1	147..173	CDD:320222	10/25 (40%)
		TM helix 2	180..206	CDD:320222	12/25 (48%)
		TM helix 3	217..247	CDD:320222	14/29 (48%)
		TM helix 4	259..281	CDD:320222	4/21 (19%)
		TM helix 5	308..337	CDD:320222	7/28 (25%)
		TM helix 6	352..382	CDD:320222	13/30 (43%)
		TM helix 7	396..421	CDD:320222	12/24 (50%)
OPRD1	NP_000902.3	7tmA_Delta_opioid_R	50..329	CDD:320217	105/282 (37%)
		TM helix 1	51..77	CDD:320217	10/25 (40%)
		TM helix 2	84..110	CDD:320217	12/25 (48%)
		TM helix 3	121..151	CDD:320217	14/29 (48%)
		TM helix 4	163..185	CDD:320217	4/21 (19%)
		TM helix 5	209..239	CDD:320217	7/29 (24%)
		TM helix 6	258..284	CDD:320217	9/25 (36%)
		TM helix 7	297..322	CDD:320217	12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..372		8/40 (20%)