Protein Alignment AstC-R2 and NMBR

DIOPT Version :10

• Sequence 1: NP_001303398.1
• Gene: AstC-R2 / 40019
• FlyBaseID: FBgn0036789
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_002502.2
• Gene: NMBR / 4829
• HGNCID: 7843
• Length: 390
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 103/390 - (26%)
• Similarity: 164/390 - (42%)
• Gaps: 71/390 - (18%)

  Fly    65 SLITPTEQLAVAPNGTTLHQLESVESESYPSINGTQNETMVTSVRPHLDHRNRPTQQNGSHYLEY 129
            |:.|...:....|.|.        |.:..|:.:||..|.::..|.|.
Human    10 SVTTGANESGSVPEGW--------ERDFLPASDGTTTELVIRCVIPS------------------ 48

  Fly   130 DDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECF 194
                                 ||.|:..:||.||.:::.:.:..|.|::|.||:|.|||..|...
Human    49 ---------------------LYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLL 92

  Fly   195 LIG-IPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIF-LLIMSADRYIAVCHPI----SSP 253
            |:. :|..........|.||...||...| ..:||...|:| |..:|||||.|:.:|:    |..
Human    93 LLTCVPVDASRYFFDEWMFGKVGCKLIPV-IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGA 156

  Fly   254 RYRTPFVSKLVSAFA-WMTSVLLMLPVILFASTVQSS---NGNVSCNIEWPDTQNSHTDSTFILY 314
            ..||     .|.|.. |:.||||.:|..:|:...:.|   |.:.:..|.:|.|...|.....:|.
Human   157 LLRT-----CVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLI 216

  Fly   315 SLVLGFATPLTFILVFYC----LVIRKLHTVGPKHKSKEKKR--SHRKVTKLVLTVISAYIFCWL 373
            .||. |..||..|.::|.    .:|:..|.:..::....||:  :.:::.|:||..:..:||||.
Human   217 FLVY-FLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWF 280

  Fly   374 PHWISQVALISSAPQRCASRLELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKACTCAARK 438
            |:.|..:....:..:...|...:.|.|....||:.||.:||.....||::|::.| .:..|..||
Human   281 PNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHF-NSQLCCGRK 344

  Fly   439  438
            Human   345  344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tmA_AstC_insect	146..428	CDD:320222	88/297 (30%)
		TM helix 1	147..173	CDD:320222	7/25 (28%)
		TM helix 2	180..206	CDD:320222	9/26 (35%)
		TM helix 3	217..247	CDD:320222	14/30 (47%)
		TM helix 4	259..281	CDD:320222	8/22 (36%)
		TM helix 5	308..337	CDD:320222	9/32 (28%)
		TM helix 6	352..382	CDD:320222	9/31 (29%)
		TM helix 7	396..421	CDD:320222	8/24 (33%)
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		2/11 (18%)
		7tmA_NMBR	44..335	CDD:320253	90/336 (27%)
		TM helix 1	45..71	CDD:320253	9/64 (14%)
		TM helix 2	78..104	CDD:320253	9/25 (36%)
		TM helix 3	116..146	CDD:320253	14/30 (47%)
		TM helix 4	158..178	CDD:320253	9/24 (38%)
		TM helix 5	209..234	CDD:320253	8/25 (32%)
		TM helix 6	259..289	CDD:320253	9/29 (31%)
		TM helix 7	303..328	CDD:320253	8/24 (33%)