DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and CXCR2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001161770.1	Gene:	CXCR2 / 3579	HGNCID:	6027	Length:	360	Species:	Homo sapiens

Alignment Length:	333	Identity:	98/333 - (29%)
Similarity:	163/333 - (48%)	Gaps:	57/333 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GPDCS-YSYN-----FIL-------------KLITMILYALVCIIGLFGNTLVIYVVMRFSKMQT 178
            |.|.| |||:     |:|             |...:|:||||.::.|.||:||:.|::.....::
Human    17 GEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRS 81

  Fly   179 VTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRY 243
            ||::|:||||:||..|.:.:| :....:|..|.||.::||...:...:..::..:.|..:|.|||
Human    82 VTDVYLLNLALADLLFALTLP-IWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRY 145

  Fly   244 IAVCH---PISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDTQNS 305
            :|:.|   .::..||...|:...:    |..|:||.|||:||..||.|||.:.:|   :.|..|:
Human   146 LAIVHATRTLTQKRYLVKFICLSI----WGLSLLLALPVLLFRRTVYSSNVSPAC---YEDMGNN 203

  Fly   306 HTDSTFILYSL--VLGFATPLTFILVFYCLVIR---KLHTVGPKHKSKEKKRSHRKVTKLVLTVI 365
            ..:...:|..|  ..||..||..:|..|...:|   |.| :|.||::          .:::..|:
Human   204 TANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAH-MGQKHRA----------MRVIFAVV 257

  Fly   366 SAYIFCWLPHWISQVALISSAPQR-------CASRLELAVFL-ACGCLSYSNSAMNPILYAFLSD 422
            ..::.||||:   .:.|::....|       |..|..:...| |...|...:|.:||::|||:..
Human   258 LIFLLCWLPY---NLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQ 319

  Fly   423 NFKKSFMK 430
            .|:...:|
Human   320 KFRHGLLK 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	65/223 (29%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	78/270 (29%)
CXCR2	NP_001161770.1	7tmA_CXCR1_2	49..325	CDD:341333	88/297 (30%)
		TM helix 1	51..75	CDD:341333	11/23 (48%)
		TM helix 2	84..105	CDD:341333	9/21 (43%)
		TM helix 3	120..142	CDD:341333	2/21 (10%)
		TM helix 4	164..180	CDD:341333	6/19 (32%)
		TM helix 5	209..232	CDD:341333	7/22 (32%)
		TM helix 6	250..272	CDD:341333	5/24 (21%)
		TM helix 7	293..318	CDD:341333	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910