DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and GPR149

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001033794.1	Gene:	GPR149 / 344758	HGNCID:	23627	Length:	731	Species:	Homo sapiens

Alignment Length:	313	Identity:	60/313 - (19%)
Similarity:	109/313 - (34%)	Gaps:	112/313 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 ITMILYALVCII---GLFGNTLVIYVVMRFSKMQ--TVTNIYILNLAIADECFLIGIPFLLYTMQ 206
            :.:.|:.|.|::   .|.|:   ||.::...|||  ||.::.:.:.::.|...::.:...::.
Human    32 LNIYLFCLTCLMTFAALVGS---IYSLISLLKMQNRTVVSMLVASWSVDDLMSVLSVTIFMFL-- 91

  Fly   207 VGNWP-----FGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKL--- 263
              .||     :..::|.           ||::..|          |..:||....|..||..
Human    92 --QWPNEVPGYFQFLCT-----------TSALMYL----------CQGLSSNLKATLLVSYNFYT 133

  Fly   264 -------------------VSAFAWMTSVLL-MLPVILFASTVQSSNGNVSCNIEWPDTQNSHTD 308
                               |....|..|:|| .||:..:.:.|::..|   |.:   |..:|:..
Human   134 MHRGVGSQTASRRSGQVLGVVLTVWAASLLLSALPLCGWGAFVRTPWG---CLV---DCSSSYVL 192

  Fly   309 STFILYS----LVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYI 369
            ...|:|:    |::|.:.|||..|:  |              |:|..|.|....:
Human   193 FLSIVYALAFGLLVGLSVPLTHRLL--C--------------SEEPPRLHSNYQE---------- 231

  Fly   370 FCWLPHWISQVALISSAPQRCASRLEL--------AVFLACGCLSYSNSAMNP 414
                   ||:.|.|...|......:.|        ::..:.||...|::...|
Human   232 -------ISRGASIPGTPPTAGRVVSLSPEDAPGPSLRRSGGCSPSSDTVFGP 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	48/252 (19%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	56/295 (19%)
GPR149	NP_001033794.1	7tmA_GPR149	35..374	CDD:320139	60/310 (19%)
		TM helix 1	35..61	CDD:320139	7/28 (25%)
		TM helix 2	67..92	CDD:320139	1/28 (4%)
		TM helix 3	105..135	CDD:320139	10/50 (20%)
		TM helix 4	150..170	CDD:320139	7/19 (37%)
		TM helix 5	196..221	CDD:320139	10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..271		6/36 (17%)
		TM helix 6	303..333	CDD:320139
		TM helix 7	341..366	CDD:320139
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100