DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and Ptgdr2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001012070.1	Gene:	Ptgdr2 / 309212	RGDID:	1311986	Length:	403	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	102/420 - (24%)
Similarity:	169/420 - (40%)	Gaps:	94/420 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PTQQNGSHYLEYDDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVV---MRFSKMQTV 179
            |...|.|  |.|.|.              ::::|:.|..::||..|.|:::||   ||    |||
  Rat    20 PNHSNSS--LRYIDH--------------VSVLLHGLASLLGLVENGLILFVVGCRMR----QTV 64

  Fly   180 TNIYILNLAIADECFLIGIPFLLYTMQVG-NWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRY 243
            ...::|:||::|......:||..|.:.|| :|..|...||.:.....:..|.|...|..:|.||.
  Rat    65 VTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRC 129

  Fly   244 IAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEW--------P 300
            :.|..|:.:..:||...:..|....|..:||..:|..:|..|:...:|.:.|....        .
  Rat   130 LQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDR 194

  Fly   301 DTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVI 365
            ||...:......:...:|.|..||..|...:..|..:||     |:.::  |:.|.| :||..::
  Rat   195 DTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLH-----HRGRQ--RTGRFV-RLVAAIV 251

  Fly   366 SAYIFCWLPHWISQVALISSAPQRCASRLELA----VFLACGCLSYSNSAMNPILYAFLSDNFKK 426
            .|:|.||.|:.|  .:|:.:......:..:||    .|:.  .|::.||.:||:||..
  Rat   252 VAFILCWGPYHI--FSLLEARAHSVTTLRQLASRGLPFVT--SLAFFNSVVNPLLYVL------- 305

  Fly   427 SFMKACTC-----AARKDVNAQLQ---LENSFFPKFGKGRQSERLLGGNGKGGAQRGALTKKKCL 483
                  ||     ..|:.:...|:   :|:|..              ..|.|         |:|
  Rat   306 ------TCPDMLHKLRRSLLTVLESVLVEDSDL--------------STGPG---------KRC- 340

  Fly   484 ATRNNNAPMATTTTTTTTTTGTDAVTCLQP 513
             .|.:....::|||..:|....|....|:|
  Rat   341 -RRRHRRRASSTTTPASTLLLADRFPQLRP 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	61/227 (27%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	72/270 (27%)
Ptgdr2	NP_001012070.1	7tm_GPCRs	32..314	CDD:421689	80/324 (25%)
		TM helix 1	33..59	CDD:410628	8/25 (32%)
		TM helix 2	65..90	CDD:410628	7/24 (29%)
		TM helix 3	103..133	CDD:410628	8/29 (28%)
		TM helix 4	145..165	CDD:410628	4/19 (21%)
		TM helix 5	202..227	CDD:410628	5/24 (21%)
		TM helix 6	238..268	CDD:410628	12/34 (35%)
		TM helix 7	282..307	CDD:410628	8/39 (21%)
		Involved in the recycling of CRTH2. /evidence=ECO:0000250	329..332		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..353		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..403
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100