DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and GPR171

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_037440.3	Gene:	GPR171 / 29909	HGNCID:	30057	Length:	319	Species:	Homo sapiens

Alignment Length:	324	Identity:	88/324 - (27%)
Similarity:	153/324 - (47%)	Gaps:	37/324 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 LKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPF-LLYTMQV 207
            |:..|...| ||.::|:.|:....:..::.:......:||::||..||....:.:|. ::..:.|
Human    14 LEPFTYFFY-LVFLVGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGV 77

  Fly   208 GNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTS 272
            ..|....:.|:.......|..:.|.|||..:|.||.:.:.|.....|.:.|..:|::|...|:..
Human    78 APWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTHSCKIYRIQEPGFAKMISTVVWLMV 142

  Fly   273 VLLMLPVILFASTVQSSNGNVSCNIEWPDT--QNSHTDSTFILYSLVLGFATPLTFILVFYCLVI 335
            :|:|:|.::..........||.| :|:...  :|.|..:.||..::.|.|:   ..||:..||||
Human   143 LLIMVPNMMIPIKDIKEKSNVGC-MEFKKEFGRNWHLLTNFICVAIFLNFS---AIILISNCLVI 203

  Fly   336 RKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWI-------SQVALISSAPQRCASR 393
            |:|:    ::|..|...:.:|....:|.|.:.||.|::|:.|       ||..:|:.    |::|
Human   204 RQLY----RNKDNENYPNVKKALINILLVTTGYIICFVPYHIVRIPYTLSQTEVITD----CSTR 260

  Fly   394 LEL-----AVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKACTCAARKDVNAQ---LQLENS 449
            :.|     |..|    |:.||...:||||..||..|:....:  |.|:.|:..||   |:.||:
Human   261 ISLFKAKEATLL----LAVSNLCFDPILYYHLSKAFRSKVTE--TFASPKETKAQKEKLRCENN 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	54/218 (25%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	69/269 (26%)
GPR171	NP_037440.3	7tmA_GPR171	15..296	CDD:320295	79/297 (27%)
		TM helix 1	17..41	CDD:320295	6/24 (25%)
		TM helix 2	50..71	CDD:320295	7/20 (35%)
		TM helix 3	88..110	CDD:320295	5/21 (24%)
		TM helix 4	133..149	CDD:320295	4/15 (27%)
		TM helix 5	177..200	CDD:320295	7/25 (28%)
		TM helix 6	222..244	CDD:320295	7/21 (33%)
		TM helix 7	264..289	CDD:320295	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910