DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and CXCR3

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001136269.1	Gene:	CXCR3 / 2833	HGNCID:	4540	Length:	415	Species:	Homo sapiens

Alignment Length:	430	Identity:	103/430 - (23%)
Similarity:	176/430 - (40%)	Gaps:	76/430 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGGRLGGKAIMEGHSTPNGAAASHRNNSTRTNIATNGCAHSGILLFVLTAMTLTSLIT-PTEQLA 74
            |.|||.|..|        |.||..::.:...:|               |...|..|.| |:...
Human     7 GPGRLAGTVI--------GGAAQSKSQTKSDSI---------------TKEFLPGLYTAPSSPF- 47

  Fly    75 VAPNGTTLHQLESVESESYPSINGTQNETMVTSVRPHLDHRNRPTQQNGSHYLEYDDD----GPD 135
             .|:..:.||:          :|..:...::.:.....|            |.|.:.|    .|.
Human    48 -PPSQVSDHQV----------LNDAEVAALLENFSSSYD------------YGENESDSCCTSPP 89

  Fly   136 C--SYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGI 198
            |  .:|.||. :.....||:|:.::||.||..|..|::......:.|:.::|:||:||...::.:
Human    90 CPQDFSLNFD-RAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTL 153

  Fly   199 PFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKL 263
            |.......| .|.||:.:||......:|..:..::.|..:|.|||:.:.|.....|...|....|
Human   154 PLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTL 217

  Fly   264 VSAFAWMTSVLLMLPVILFASTVQSSNGNVS-CNIEWPDTQNSHTDSTFILYSLVLGFATPLTFI 327
            .....|...:|..||..:|.|.......|.: |...:|....    :...:..||.||..||  :
Human   218 TCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGR----TALRVLQLVAGFLLPL--L 276

  Fly   328 LVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLP-HWISQVAL---ISSAPQ 388
            ::.||..    |.:.....|:.::|  .:..:||:.|:.|:..||.| |.:..|.:   :.:..:
Human   277 VMAYCYA----HILAVLLVSRGQRR--LRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALAR 335

  Fly   389 RCA--SRLELAVFLACGCLSYSNSAMNPILYAFLSDNFKK 426
            .|.  ||:::|..:..| |.|.:..:||:||||:...|::
Human   336 NCGRESRVDVAKSVTSG-LGYMHCCLNPLLYAFVGVKFRE 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	53/216 (25%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	65/261 (25%)
CXCR3	NP_001136269.1	7tmA_CXCR3	101..376	CDD:341335	75/288 (26%)
		TM helix 1	101..128	CDD:341335	9/26 (35%)
		TM helix 2	135..160	CDD:341335	7/24 (29%)
		TM helix 3	171..201	CDD:341335	8/29 (28%)
		TM helix 4	213..235	CDD:341335	5/21 (24%)
		TM helix 5	259..288	CDD:341335	9/38 (24%)
		TM helix 6	295..325	CDD:341335	9/31 (29%)
		TM helix 7	344..369	CDD:341335	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910