DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and NPBWR1

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_005276.2	Gene:	NPBWR1 / 2831	HGNCID:	4522	Length:	328	Species:	Homo sapiens

Alignment Length:	333	Identity:	116/333 - (34%)
Similarity:	182/333 - (54%)	Gaps:	25/333 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 NRPTQQNGSHYLEYDDDGPD----CSYSYNFI-----LKLITMILYALVCIIGLFGNTLVIYVVM 171
            :.|...|.|        |||    ||.:....     |.:...::||::|.:||.||:.|:||::
Human     7 SEPWPANAS--------GPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLL 63

  Fly   172 RFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLL 236
            |..:|:||||::|||||||||.|.:.:|..:....:..||||..|||..:......:|:|..||.
Human    64 RAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128

  Fly   237 IMSADRYIAVCHPISSPRY--RTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEW 299
            :||||||:.|.....|.|.  ||...::.||...|....|::||..:|| .:....|...|.:.:
Human   129 VMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFA-RLDDEQGRRQCVLVF 192

  Fly   300 PDTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTV 364
            |..:.....:: .||:||||||.|::.|.|.|..::.:||.:.....:|..:|:.::||.||:.:
Human   193 PQPEAFWWRAS-RLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAI 256

  Fly   365 ISAYIFCWLPHWISQ-VALISSAPQRCASRLELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSF 428
            ::..:.||.|:.:|. |||.:..||   :.|.:|:......|||:||.:||.|||||..:|:::.
Human   257 LAVCLLCWTPYHLSTVVALTTDLPQ---TPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318

  Fly   429 MKACTCAA 436
            .:..||.|
Human   319 RQLITCRA 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	78/217 (36%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	93/257 (36%)
NPBWR1	NP_005276.2	7tmA_NPBWR	47..318	CDD:320215	102/275 (37%)
		TM helix 2	72..98	CDD:320215	13/25 (52%)
		TM helix 3	109..139	CDD:320215	12/29 (41%)
		TM helix 4	153..175	CDD:320215	6/21 (29%)
		TM helix 5	200..229	CDD:320215	12/29 (41%)
		TM helix 6	244..274	CDD:320215	9/29 (31%)
		TM helix 7	286..311	CDD:320215	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010