DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and XCR1

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001019815.1	Gene:	XCR1 / 2829	HGNCID:	1625	Length:	333	Species:	Homo sapiens

Alignment Length:	307	Identity:	88/307 - (28%)
Similarity:	153/307 - (49%)	Gaps:	30/307 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 YLEYDDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIA 190
            :..||.....|.........|.|.:||.||.::.|.||:||::|::::..::::|||:||||.::
Human    12 FFYYDLQSQPCENQAWVFATLATTVLYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFILNLCLS 76

  Fly   191 DECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRY 255
            |..|...:|..:.....| |..|:::||...:..||:.::|..||.||:..||::|..|:|:.|.
Human    77 DLVFACLLPVWISPYHWG-WVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLSTLRV 140

  Fly   256 RTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLV--- 317
            .|.....||:...|:.|:|..:...:|...:.|     .|:         :::.|:.|.|:.
Human   141 PTLRCRVLVTMAVWVASILSSILDTIFHKVLSS-----GCD---------YSELTWYLTSVYQHN 191

  Fly   318 LGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWIS---Q 379
            |.|...|..||..|..::|.|      .:|:.|:| ||.| ||:..::.||...|.|:..:   |
Human   192 LFFLLSLGIILFCYVEILRTL------FRSRSKRR-HRTV-KLIFAIVVAYFLSWGPYNFTLFLQ 248

  Fly   380 VALISSAPQRCASRLELA-VFLACGCLSYSNSAMNPILYAFLSDNFK 425
            ....:...:.|.::.:|. ..|.|..|::|:...||:||.|:...|:
Human   249 TLFRTQIIRSCEAKQQLEYALLICRNLAFSHCCFNPVLYVFVGVKFR 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	64/218 (29%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	74/261 (28%)
XCR1	NP_001019815.1	7tmA_XCR1	32..298	CDD:341337	85/287 (30%)
		TM helix 1	34..58	CDD:341337	11/23 (48%)
		TM helix 2	67..88	CDD:341337	9/20 (45%)
		TM helix 3	103..125	CDD:341337	8/21 (38%)
		TM helix 4	148..164	CDD:341337	5/15 (33%)
		TM helix 5	183..206	CDD:341337	7/22 (32%)
		TM helix 6	224..246	CDD:341337	7/22 (32%)
		TM helix 7	266..291	CDD:341337	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910