DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and Gpr1

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001343974.1	Gene:	Gpr1 / 241070	MGIID:	2385324	Length:	353	Species:	Mus musculus

Alignment Length:	376	Identity:	113/376 - (30%)
Similarity:	187/376 - (49%)	Gaps:	55/376 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NGSHYLEY--DDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYI 184
            |.|:.|:|  .:..|: ...|..::..|::.||||..::|:.||.:||: :|.|...:|||.::.
Mouse    14 NYSYALDYYSQESDPE-EKVYLGLVHWISLFLYALAFVLGIPGNAIVIW-LMGFKWKKTVTTLWF 76

  Fly   185 LNLAIADECFLIGIP-FLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCH 248
            |||||||..|::.:| ::.|.....:||||.::||.......:..|:|..||.::|.||||.:.|
Mouse    77 LNLAIADFIFVLFLPLYISYVALSFHWPFGLWLCKVNSFIAQLNMFSSVFFLTVISLDRYIHLLH 141

  Fly   249 PISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPD---TQNSHTDST 310
            |..|.|:||...|.:|....|:.:.||..|.:.|..|::.:| ::.|...:.:   |...|...|
Mouse   142 PGLSHRHRTLKSSLVVVILVWLLASLLGGPTLYFRDTMEVNN-HIICYNNFQEHELTLMRHHVLT 205

  Fly   311 FILYSLVLGFATP-LTFILVFYCLVIRKLHTVGPKHKSKEKKRS---HRKVTKLVLTVISAYIFC 371
            ::.:  :.|:..| ||....:.||:.            |.|||:   .||...::|:|:.|::.|
Mouse   206 WVKF--LFGYLFPLLTMSSCYLCLIF------------KMKKRNILISRKHLWMILSVVIAFLVC 256

  Fly   372 WLPHWISQVALIS----SAPQRCASRLELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKAC 432
            |.|:.:..:..:|    |:.|..   |:..:.|:.| |::.||.:|||||..:|..|:..|.
Mouse   257 WTPYHLFSIWELSIHHNSSFQNV---LQGGIPLSTG-LAFLNSCLNPILYVLISKTFQARFR--- 314

  Fly   433 TCAARKDVNAQLQLENSFFPKFGKGRQSERLLGGNGKGGAQRGALTKKKCL 483
              |:..:|     |:.|.:.....|..||:|          |.|.||...|
Mouse   315 --ASVAEV-----LKRSLWEASCSGTVSEQL----------RSAETKSLSL 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	69/223 (31%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	83/266 (31%)
Gpr1	NP_001343974.1	7tmA_GPR1	39..313	CDD:320247	93/293 (32%)
		TM helix 1	40..66	CDD:320247	11/26 (42%)
		TM helix 2	72..97	CDD:320247	10/24 (42%)
		TM helix 3	110..140	CDD:320247	11/29 (38%)
		TM helix 4	152..172	CDD:320247	5/19 (26%)
		TM helix 5	201..226	CDD:320247	6/26 (23%)
		TM helix 6	237..267	CDD:320247	8/29 (28%)
		TM helix 7	281..306	CDD:320247	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010