DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and npr-26

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001299957.1	Gene:	npr-26 / 24104836	WormBaseID:	WBGene00011372	Length:	461	Species:	Caenorhabditis elegans

Alignment Length:	522	Identity:	125/522 - (23%)
Similarity:	200/522 - (38%)	Gaps:	130/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 TPTEQLAVAPNGTTLHQLESVESESY--------PSINGTQNETMVTSVRPHLDHRNRPTQQNGS 124
            ||..|..:......|....|.|.|.|        .|||.|..:                .|.:|.
Worm    13 TPPPQQPLQQKSLFLKMDASTEFEIYREHYSRVMASINATMCQ----------------EQPDGI 61

  Fly   125 HYLEYDDDGPDCSYS-YNFILK-----LITMILYALVCIIGLFGNTLVIYVV--------MRFSK 175
            .|......||....: |..|.:     ||.::::.|..|:|:.||:.:|.::        .|..:
Worm    62 LYCPNHTGGPVWVRNVYPPIQELQPKVLIVVVVFVLCFIVGVCGNSSIITIIRGVVEDRRKRMKR 126

  Fly   176 MQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSA 240
            ......:||..|.:.|....:.:|..:....:|.|.||..|||.:.|..|:....|:..:..||.
Worm   127 HGDNAILYIGALCVCDFVMSLSLPPAILDSVIGFWIFGTTMCKVHHVFGSVGRIASTFLITAMSF 191

  Fly   241 DRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSV--LLMLPVILFAS----TVQSSNGNVSCNIE- 298
            |||:|||:|   ..:|....:.::|..|.::|:  :|:||::.:||    .:.....:.|.||.
Worm   192 DRYVAVCYP---HHHRLRSRTFVISTIACLSSIAFVLLLPMLTYASAKEMVLHELKAHESANITR 253

  Fly   299 ----------------WPDTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKS 347
                            |      .|.:|||     ||:..||..|:.|...:|.||:.    ||
Worm   254 VRVFKCSDMMPGPIFYW------FTSTTFI-----LGYVVPLILIVYFNLKLINKLYA----HK- 302

  Fly   348 KEKKRSH---RKVTKLVLTVISAYIFCWLPHWISQV-ALISSAPQRCASRLELAVFLACGC---L 405
            :...||.   |:|....:.:.:.|..||.|:|.|.: |:|.|...:..:..|..:| |..|   |
Worm   303 RVLPRSAIPVRRVVVYTVLIAAVYFVCWTPYWFSVLYAIIMSLLGKPTTNSEWVLF-AIYCVHLL 366

  Fly   406 SYSNSAMNPILYAFLSDNFKKSFMKACTCAARKDVNAQLQLENSFFPKFGKGRQSERLLGGNGKG 470
            .|..|:.|.|||..|                    |.|||::|..      |...:.::..||..
Worm   367 PYFGSSSNWILYGLL--------------------NTQLQMKNDI------GDDGQSIMTTNGVQ 405

  Fly   471 GAQRGALTKKKCLATRNNNAPMATTTTTTTTTTGTDAVTCLQPPVHQVPAEIQVGNPATVLVVNA 535
            ...|.:.::..|.|...::..:.|..|                |:.|..:.:..||..|.:|...
Worm   406 DLPRRSTSRLICDAGATSSRSIPTNNT----------------PLWQNDSTLTRGNSDTSMVFYQ 454

  Fly   536 ET 537
            :|
Worm   455 DT 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	63/249 (25%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	78/292 (27%)
npr-26	NP_001299957.1	7tm_classA_rhodopsin-like	102..382	CDD:381740	82/319 (26%)
		TM helix 2	129..153	CDD:381740	5/23 (22%)
		TM helix 3	169..191	CDD:381740	5/21 (24%)
		TM helix 4	213..229	CDD:381740	5/15 (33%)
		TM helix 5	269..292	CDD:381740	11/33 (33%)
		TM helix 6	313..341	CDD:381740	8/27 (30%)
		TM helix 7	354..382	CDD:381740	12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010