DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and Sstr4

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_033245.2	Gene:	Sstr4 / 20608	MGIID:	105372	Length:	385	Species:	Mus musculus

Alignment Length:	383	Identity:	128/383 - (33%)
Similarity:	207/383 - (54%)	Gaps:	67/383 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNY 215
            :|||||::||.||.|||:|::|::||:|.||||:||||:|||.|::.:||:.....:.:||||..
Mouse    50 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAV 114

  Fly   216 MCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVI 280
            :|:|.:....:..|||...|.::|.|||:||.||:.:..||.|.|:||::...|:.|:|:.||:.
Mouse   115 LCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIA 179

  Fly   281 LFASTVQSSNGN-VSCNIEWPDTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPK 344
            :||.|..:..|. |:||:.||....|   :.|::|:.:|||..|:..|.:.|.|::.|:..|..:
Mouse   180 VFADTRPARGGEAVACNLHWPHPAWS---AVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALR 241

  Fly   345 HKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLACGCLSYSN 409
            ...::::||.:|:|:|||.|::.::.||:|.::.|:..:      ..:.|:..|......|||:|
Mouse   242 AGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL------FVTSLDATVNHVSLILSYAN 300

  Fly   410 SAMNPILYAFLSDNFKKSF-----MKACTCAARKDVNAQLQLENSFFPKFGKGRQSERLLGGNGK 469
            |..|||||.||||||::||     ::.|.            ||.:
Mouse   301 SCANPILYGFLSDNFRRSFQRVLCLRCCL------------LETT-------------------- 333

  Fly   470 GGAQRGALTKKKCLATRNNNAPMATTTTTTTTTTGTDAVTCLQPPV--HQVPAEIQVG 525
            |||:               ..|:....|...:..|..   |:.||:  .|.|.:.:.|
Mouse   334 GGAE---------------EEPLDYYATALKSRGGAG---CICPPLPCQQEPVQAEPG 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	85/216 (39%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	96/255 (38%)
Sstr4	NP_033245.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		7tmA_SSTR4	45..319	CDD:320639	111/277 (40%)
		TM helix 1	46..72	CDD:320639	13/21 (62%)
		TM helix 2	79..105	CDD:320639	14/25 (56%)
		TM helix 3	116..146	CDD:320639	11/29 (38%)
		TM helix 4	158..180	CDD:320639	8/21 (38%)
		TM helix 5	205..234	CDD:320639	10/31 (32%)
		TM helix 6	249..279	CDD:320639	12/29 (41%)
		TM helix 7	287..312	CDD:320639	12/24 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2540
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20286
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8844
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.910