DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and Sstr2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001036071.1	Gene:	Sstr2 / 20606	MGIID:	98328	Length:	369	Species:	Mus musculus

Alignment Length:	338	Identity:	140/338 - (41%)
Similarity:	205/338 - (60%)	Gaps:	19/338 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 SYPSINGTQNETMVTSVRPHLDHRNRPTQQNGSHYLEYDDDGPDCSYSYNFILKLITMILYALVC 156
            |...:||:|     ..|....|........|||:..|     |....:.|.:|..|    |.:||
Mouse     4 SSEQLNGSQ-----VWVSSPFDLNGSLGPSNGSNQTE-----PYYDMTSNAVLTFI----YFVVC 54

  Fly   157 IIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYM 221
            ::||.||||||||::|::||:|:|||||||||||||.|::|:|||...:.:.:||||..:|:..|
Mouse    55 VVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVM 119

  Fly   222 VSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTV 286
            ....|..|||...|.:||.|||:||.|||.|.::|.|..:|:::...|..|:|::||::::|...
Mouse   120 TVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWCVSLLVILPIMIYAGLR 184

  Fly   287 QSSNGNVSCNIEWPDTQNS-HTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEK 350
            .:..|..||.|.||....: :|.  ||:|:.:|||..|||.|.:.|..:|.|:.:.|.:..|.::
Mouse   185 SNQWGRSSCTINWPGESGAWYTG--FIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKR 247

  Fly   351 KRSHRKVTKLVLTVISAYIFCWLPHWISQVALISSAPQRCASRLELAVFLACGCLSYSNSAMNPI 415
            |:|.:|||::|..|::.:||||||.:|..|:.:|.|.....:...:..|:.  .|:|:||..|||
Mouse   248 KKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVV--ILTYANSCANPI 310

  Fly   416 LYAFLSDNFKKSF 428
            |||||||||||||
Mouse   311 LYAFLSDNFKKSF 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	95/216 (44%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	108/255 (42%)
Sstr2	NP_001036071.1	7tmA_SSTR2	44..323	CDD:320637	126/286 (44%)
		TM helix 1	45..71	CDD:320637	15/29 (52%)
		TM helix 2	78..104	CDD:320637	18/25 (72%)
		TM helix 3	115..145	CDD:320637	13/29 (45%)
		TM helix 4	157..179	CDD:320637	6/21 (29%)
		TM helix 5	205..234	CDD:320637	13/30 (43%)
		TM helix 6	249..279	CDD:320637	14/29 (48%)
		TM helix 7	291..316	CDD:320637	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850131
Domainoid	1	1.000	224	1.000	Domainoid score	I2540
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8844
orthoMCL	1	0.900	-	-		OOG6_107077
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3938
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770