DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and Sstr3

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_598206.1	Gene:	Sstr3 / 171044	RGDID:	620308	Length:	428	Species:	Rattus norvegicus

Alignment Length:	305	Identity:	109/305 - (35%)
Similarity:	184/305 - (60%)	Gaps:	19/305 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVGNW 210
            ::..::|.:||::||.||:||||||:|.:...:||::||||||:|||.|::|:|||.....:..|
  Rat    46 ILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYW 110

  Fly   211 PFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLL 275
            |||:.||:..|....|..|||...|.:||.|||:||.||..|.|:||..|:::|||..|:.|.::
  Rat   111 PFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVV 175

  Fly   276 MLPVILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHT 340
            :|||::|:..   ..|..:|:::||:...:.. :.||:|:..|||..||..|.:.|.|::.|:.:
  Rat   176 VLPVVVFSGV---PRGMSTCHMQWPEPAAAWR-TAFIIYTAALGFFGPLLVICLCYLLIVVKVRS 236

  Fly   341 VGPKHKS-----------KEKKRSHRKVTKLVLTVISAYIFCWLPHWISQVA-LISSAPQRCASR 393
            ...:.::           :.::||.|:||::|:.|::.::.||:|.::..:. ::...|:..|.
  Rat   237 TTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAF- 300

  Fly   394 LELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKACTCAARK 438
              ..::.....|.|:||..|||||.|||..||:.|.:.....:|:
  Rat   301 --FGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRR 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	86/226 (38%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	95/266 (36%)
Sstr3	NP_598206.1	7tm_GPCRs	46..333	CDD:421689	107/293 (37%)
		TM helix 1	47..73	CDD:410628	13/25 (52%)
		TM helix 2	80..106	CDD:410628	15/25 (60%)
		TM helix 3	117..147	CDD:410628	13/29 (45%)
		TM helix 4	159..181	CDD:410628	9/21 (43%)
		TM helix 5	204..233	CDD:410628	11/29 (38%)
		TM helix 6	259..289	CDD:410628	10/29 (34%)
		TM helix 7	301..326	CDD:410628	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..428		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2480
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3165
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.960