Protein Alignment AstC-R2 and Ptgdr2

DIOPT Version :10

• Sequence 1: NP_001303398.1
• Gene: AstC-R2 / 40019
• FlyBaseID: FBgn0036789
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_034092.1
• Gene: Ptgdr2 / 14764
• MGIID: 1330275
• Length: 382
• Species: Mus musculus
• Alignment Length: 420
• Identity: 104/420 - (24%)
• Similarity: 172/420 - (40%)
• Gaps: 99/420 - (23%)

  Fly   118 PTQQNGSHYLEYDDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVV---MRFSKMQTV 179
            |...|.|  |.|.|.              ::::|:.|..::||..|.|:::||   ||    |||
Mouse    20 PNHSNSS--LRYIDH--------------VSVLLHGLASLLGLVENGLILFVVGCRMR----QTV 64

  Fly   180 TNIYILNLAIADECFLIGIPFLLYTMQVG-NWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRY 243
            ...::|:||::|......:||..|.:.|| :|..|...||.:.....:..|.|...|..:|.||.
Mouse    65 VTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRC 129

  Fly   244 IAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCN---IEW-----P 300
            :.|..|:.:..:||..|:..|....|..:||..:|..:|..|:...:|.:.|.   :.|     .
Mouse   130 LQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDR 194

  Fly   301 DTQNSHTDSTFILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVI 365
            ||...:......:...:|.|..||..|...:..|..:||     |:.::  |:.|.| :||..::
Mouse   195 DTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLH-----HRGRQ--RTGRFV-RLVAAIV 251

  Fly   366 SAYIFCWLPHWISQVALISSAPQRCASRLELA----VFLACGCLSYSNSAMNPILYAFLSDNFKK 426
            .|::.||.|:.|  .:|:.:......:..:||    .|:.  .|::.||.:||:||.|
Mouse   252 VAFVLCWGPYHI--FSLLEARAHSVTTLRQLASRGLPFVT--SLAFFNSVVNPLLYVF------- 305

  Fly   427 SFMKACTC-----AARKDVNAQLQ---LENSFFPKFGKGRQSERLLGGNGKGGAQRGALTKKKCL 483
                  ||     ..|:.:.|.|:   :|:|                      .|.|.|
Mouse   306 ------TCPDMLYKLRRSLRAVLESVLVEDS----------------------DQSGGL------ 336

  Fly   484 ATRNNNAPMATTTTTTTTTTGTDAVTCLQP 513
              ||.....::|.|..:|....|.:..|:|
Mouse   337 --RNRRRRASSTATPASTLLLADRIPQLRP 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tmA_AstC_insect	146..428	CDD:320222	80/297 (27%)
		TM helix 1	147..173	CDD:320222	9/28 (32%)
		TM helix 2	180..206	CDD:320222	7/25 (28%)
		TM helix 3	217..247	CDD:320222	8/29 (28%)
		TM helix 4	259..281	CDD:320222	6/21 (29%)
		TM helix 5	308..337	CDD:320222	6/28 (21%)
		TM helix 6	352..382	CDD:320222	10/29 (34%)
		TM helix 7	396..421	CDD:320222	11/28 (39%)
Ptgdr2	NP_034092.1	7tm_GPCRs	32..314	CDD:475119	82/324 (25%)
		TM helix 1	34..58	CDD:320246	8/23 (35%)
		TM helix 2	66..87	CDD:320246	6/20 (30%)
		TM helix 3	104..126	CDD:320246	4/21 (19%)
		TM helix 4	149..165	CDD:320246	4/15 (27%)
		TM helix 5	203..226	CDD:320246	5/22 (23%)
		TM helix 6	244..266	CDD:320246	8/24 (33%)
		TM helix 7	282..307	CDD:320246	9/39 (23%)
		Involved in the recycling of CRTH2. /evidence=ECO:0000250	329..332		1/24 (4%)