DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and ACKR2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001287.2	Gene:	ACKR2 / 1238	HGNCID:	1565	Length:	384	Species:	Homo sapiens

Alignment Length:	413	Identity:	107/413 - (25%)
Similarity:	183/413 - (44%)	Gaps:	97/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 MVTSVRPH-LDHRNRPTQQNGSHYLEYDDD------GPDCSYSYNFILKLITMILYALVCIIGLF 161
            |..:..|. |...:..::.:..:|.:|.|:      ..|...|:.   |:...:.|:|:.::||.
Human     1 MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFG---KVFLPVFYSLIFVLGLS 62

  Fly   162 GNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFLLYTMQVG-NWPFGNYMCKAYMVSTS 225
            ||.|::.|::|:...:.:..||:|||||::..||:.:||  :.:.|. :|.||:::||  ||||.
Human    63 GNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPF--WGISVAWHWVFGSFLCK--MVSTL 123

  Fly   226 IT-SFTSSIFLL-IMSADRYIAVCHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQS 288
            .| :|.|.||.: .||.|:|:.:.|.....|.||...|.|::...|..|:.:.:|.::|..|.::
Human   124 YTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHEN 188

  Fly   289 SNGNVSCNIEWPDTQNSHTD--------STFILYSL-VLGFATPLTFILVFY----CLVIRKLHT 340
            ..|      .|    |.|.|        ..|:.:.. :|||..||..::.||    |:::| |..
Human   189 PKG------VW----NCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVR-LRP 242

  Fly   341 VGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLP-------HWISQVALISSAPQRCASRLELAV 398
            .|           ..:..|:...::.|:...|.|       |.:..:.:..:.  ..:..|:.|:
Human   243 AG-----------QGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNC--EVSQHLDYAL 294

  Fly   399 -------FLACGCLSYSNSAMNPILYAFLSDNFK---KSFMKA---------------CTCAARK 438
                   ||.| |.|       ||||||.|..|:   |:|:.|               .:|:...
Human   295 QVTESIAFLHC-CFS-------PILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESS 351

  Fly   439 DVNAQLQLENSFFPKFGKGRQSE 461
            .:.||.::..  ....|: ||||
Human   352 ILTAQEEMTG--MNDLGE-RQSE 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	67/231 (29%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	77/284 (27%)
ACKR2	NP_001287.2	7tmA_ACKR2_D6	47..323	CDD:320316	87/311 (28%)
		TM helix 1	47..74	CDD:320316	8/26 (31%)
		TM helix 2	81..106	CDD:320316	11/26 (42%)
		TM helix 3	117..147	CDD:320316	15/31 (48%)
		TM helix 4	159..181	CDD:320316	5/21 (24%)
		TM helix 5	207..236	CDD:320316	8/28 (29%)
		TM helix 6	243..273	CDD:320316	5/40 (13%)
		TM helix 7	291..316	CDD:320316	12/32 (38%)
		C-terminal cytoplasmic tail	327..384		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910