DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstC-R2 and Bdkrb2

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_011242293.1	Gene:	Bdkrb2 / 12062	MGIID:	102845	Length:	406	Species:	Mus musculus

Alignment Length:	400	Identity:	109/400 - (27%)
Similarity:	180/400 - (45%)	Gaps:	60/400 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ESESYPSINGTQ-------------NETMVTSVRPHLDHRNRPTQQNGS--HYLEYDDDGPDCS- 137
            |.:.:.|::|.|             :|.|.|:....::..|..||..||  :.....|:.||..
Mouse     3 EEDPHSSLSGVQMPCSWKLLGFLSVHEPMPTAASFGIEMFNVTTQVLGSALNGTLSKDNCPDTEW 67

  Fly   138 YSY-NFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFLIGIPFL 201
            :|: |.|......:|:.|..:..||    |:.|........||..||:.|||.||.....|:||
Mouse    68 WSWLNAIQAPFLWVLFLLAALENLF----VLSVFFLHKNSCTVAEIYLGNLAAADLILACGLPF- 127

  Fly   202 LYTMQVGN---WPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTPFVSKL 263
             :.:.:.|   |.||..:|:.......:..::|..||:::|.|||:|:...:|..|.|....:||
Mouse   128 -WAITIANNFDWVFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKL 191

  Fly   264 VSAFAWMTSVLLMLPVILFASTVQ-SSNGN--VSCNIEWPDTQNSHTDSTFILYSLVLGFATPLT 325
            .|...|..::||..|:::|.:..: |..|:  .:|.|.:|  ..|....|.:|.:|| ||..||:
Mouse   192 YSLVIWGCTLLLSSPMLVFRTMREYSEEGHNVTACVIVYP--SRSWEVFTNVLLNLV-GFLLPLS 253

  Fly   326 FILVFYCLVIRKLHTVGPKHKSKEKK-RSHRKVTKLVLTVISAYIFCWLPHWISQVALISSAPQR 389
              ::.:| .:|.|..:......|.|: ::.||.|.|||.|:..::.||:|..||..
Mouse   254 --VITFC-TVRILQVLRNNEMKKFKEVQTERKATVLVLAVLGLFVLCWVPFQISTF--------- 306

  Fly   390 CASRLELAVFLAC-------------GCLSYSNSAMNPILYAFLSDNFKKSFMKACTCAARKD-- 439
            ..:.|.|.|...|             ..::||||.:||::|..:...|:|...:......:|.
Mouse   307 LDTLLRLGVLSGCWDEHAVDVITQISSYVAYSNSGLNPLVYVIVGKRFRKKSREVYRVLCQKGGC 371

  Fly   440 VNAQLQLENS 449
            :...:|:|||
Mouse   372 MGEPVQMENS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	66/222 (30%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	79/274 (29%)
Bdkrb2	XP_011242293.1	7tmA_BK-2	74..358	CDD:320503	87/304 (29%)
		TM helix 1	75..99	CDD:320503	6/27 (22%)
		TM helix 2	108..129	CDD:320503	10/22 (45%)
		TM helix 3	146..168	CDD:320503	3/21 (14%)
		TM helix 4	191..207	CDD:320503	5/15 (33%)
		TM helix 5	237..260	CDD:320503	9/26 (35%)
		TM helix 6	284..306	CDD:320503	10/21 (48%)
		TM helix 7	326..351	CDD:320503	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000