DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and CCR9

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001373376.1	Gene:	CCR9 / 10803	HGNCID:	1610	Length:	369	Species:	Homo sapiens

Alignment Length:	375	Identity:	99/375 - (26%)
Similarity:	173/375 - (46%)	Gaps:	56/375 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ITPTEQLAVAPNGTTLHQLESVES-ESYPSINGTQNETMVTSVRPHLDHRNRPTQQNGSHYLEYD 130
            :|||:..:..||....:..||..| |.|.:.|.|.......:||           |..||:|
Human     1 MTPTDFTSPIPNMADDYGSESTSSMEDYVNFNFTDFYCEKNNVR-----------QFASHFL--- 51

  Fly   131 DDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILNLAIADECFL 195
               |.               ||.||.|:|..||:|||.|....::::|:|::::|||||||..||
Human    52 ---PP---------------LYWLVFIVGALGNSLVILVYWYCTRVKTMTDMFLLNLAIADLLFL 98

  Fly   196 IGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTP-- 258
            :.:||.... ....|.|..:|||.......:..::..:.::.:|.|||||:...:.:..:|..
Human    99 VTLPFWAIA-AADQWKFQTFMCKVVNSMYKMNFYSCVLLIMCISVDRYIAIAQAMRAHTWREKRL 162

  Fly   259 FVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLVLGFATP 323
            ..||:|....|:.:..|.:|.||: |.::..:|...|.:.:|..:::...|..:...::|||..|
Human   163 LYSKMVCFTIWVLAAALCIPEILY-SQIKEESGIAICTMVYPSDESTKLKSAVLTLKVILGFFLP 226

  Fly   324 LTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPH-------WISQVA 381
            ...:...|.::|   ||:     .:.||.|..|..|:.:||::.::....|:       .|...|
Human   227 FVVMACCYTIII---HTL-----IQAKKSSKHKALKVTITVLTVFVLSQFPYNCILLVQTIDAYA 283

  Fly   382 LISSAPQRCASRLELAV-FLACGCLSYSNSAMNPILYAFLSDNFKKSFMK 430
            :..|   .||....:.: |.....:::.:|.:||:||.|:.:.|::..:|
Human   284 MFIS---NCAVSTNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVK 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	61/217 (28%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	69/264 (26%)
CCR9	NP_001373376.1	7tmA_CCR9	49..328	CDD:320302	82/312 (26%)
		TM helix 1	51..75	CDD:320302	14/44 (32%)
		TM helix 2	84..105	CDD:320302	11/20 (55%)
		TM helix 3	120..142	CDD:320302	1/21 (5%)
		TM helix 4	167..183	CDD:320302	3/15 (20%)
		TM helix 5	212..235	CDD:320302	5/22 (23%)
		TM helix 6	253..275	CDD:320302	4/21 (19%)
		TM helix 7	296..321	CDD:320302	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910