DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and LPAR6

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001155969.1	Gene:	LPAR6 / 10161	HGNCID:	15520	Length:	344	Species:	Homo sapiens

Alignment Length:	332	Identity:	84/332 - (25%)
Similarity:	152/332 - (45%)	Gaps:	37/332 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NGSHYLEYDDDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTNIYILN 186
            |.||          |.|:.:|...|.. .::::|.::||..|.:.||:.:...|::..|..|::|
Human     5 NSSH----------CFYNDSFKYTLYG-CMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMIN 58

  Fly   187 LAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAVCHPIS 251
            ||::|..|:..:||.::.....|||||:.:||..::......:.|.:||..:|.||::|:.:|..
Human    59 LAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFK 123

  Fly   252 SPRYRTPFVSKLVSAFAWMTSVLLMLPVILFAST-VQSSNGNVSCNIEWPDTQNSHTDSTFILYS 315
            |...||...:|:|....|:|.:....|.:...|| .|.:|.:.:|...:|:.......|..:::.
Human   124 SKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFI 188

  Fly   316 LVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPHWISQV 380
            .::||..||...:....:|::.|.......:||..|   .||.|::...:..:.||::|:.|:.:
Human   189 EIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINK---TKVLKMIFVHLIIFCFCFVPYNINLI 250

  Fly   381 ALISSAPQRCASRLELAVFLACG-------------CLSYSNSAMNPILYAFLSDNFKKSFMKAC 432
            ..         |.:....|:.|.             |::.||...:||:|.|.||..:.|.....
Human   251 LY---------SLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKN 306

  Fly   433 TCAARKD 439
            ....|.|
Human   307 WSVRRSD 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	58/216 (27%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	67/268 (25%)
LPAR6	NP_001155969.1	7tmA_LPAR6_P2Y5	18..302	CDD:320284	75/296 (25%)
		TM helix 1	20..44	CDD:320284	6/24 (25%)
		TM helix 2	53..74	CDD:320284	8/20 (40%)
		TM helix 3	90..112	CDD:320284	4/21 (19%)
		TM helix 4	135..151	CDD:320284	3/15 (20%)
		TM helix 5	182..205	CDD:320284	5/22 (23%)
		TM helix 6	228..250	CDD:320284	5/21 (24%)
		TM helix 7	270..295	CDD:320284	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910