DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and gpr149

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_002933305.3	Gene:	gpr149 / 100497416	XenbaseID:	XB-GENE-983069	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	416	Identity:	83/416 - (19%)
Similarity:	143/416 - (34%)	Gaps:	151/416 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 SVRPHLDHRNRPTQQNGSHYLEYD---DDGPDCSYSYNFILKLITMILYALVCIIGLFGNTLVIY 168
            ||.|.|    .||  ||:.: |.|   .|.|..::::|.::..:|:|:     .:.:|..:::..
Frog     2 SVIPTL----LPT--NGTRF-EPDLGIMDMPKATFTFNALVFSLTLII-----TLTVFLGSIISL 54

  Fly   169 VVMRFSKMQTVTNIYILNLAIADECFLIGIP----FLLYTMQVGNWPFGNYMCKA----YM---V 222
            |.:...|.::..::.:.:|::.|   |:.:.    |:|:.......|  ..:|.|    |:   :
Frog    55 VSLLKMKSKSTLSLLVTSLSVDD---LVSVVPASIFMLHQWTTHALP--QPLCSAAAFLYLFQGI 114

  Fly   223 STSITSFTSSIFLLIMSADRYIAVCHPISSPR----YRTPFVS-KLVSAFA--WMTSVLL-MLPV 279
            |:::.:  |||            :|:...:..    |.|..:| |:..|.|  |:.|:|: .:|.
Frog   115 SSNLKA--SSI------------ICYNFYTVNKLGSYETTKISVKIFCAVATIWVISILISAIPF 165

  Fly   280 ILFASTVQSSNGNVSCNIEWPDTQNSHTDSTFILYSLVL-------------------------- 318
            ..:.....:|.|   |   :.|..:|:....|.||||..
Frog   166 FGWGRFHTTSWG---C---FTDCTSSYILFLFGLYSLCFCILVILSAPLTHQLLCSDDHQHINYK 224

  Fly   319 ----GFATPLTFI----------------------------LVFYCLVIRKLHTVGPKHKSKEKK 351
                |:.||.|.:                            .||...|   ..|.|....|....
Frog   225 DISKGYLTPTTPLGSNASSLSPDNPVGKTLKNSNEKYVSPEAVFKRSV---AETSGDVQHSSNSV 286

  Fly   352 RSHRKVTKLV------LTVISAYIFCWLPHWISQV-------------------ALISSAPQRCA 391
            |..|.:|.|.      |.:....:..|||..|..|                   :|:|:|.....
Frog   287 RGGRNITVLYAQKRFSLILALTKVILWLPIMIQMVVQHIVAFQSLSFETLSFILSLLSAAATPLF 351

  Fly   392 SRLELAVFLACGCL------SYSNSA 411
            ...|....|.|||:      :|..||
Frog   352 VLSERWRHLPCGCIINCKRNTYETSA 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	52/298 (17%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	67/358 (19%)
gpr149	XP_002933305.3	7tmA_GPR149	34..364	CDD:320139	65/362 (18%)
		TM helix 1	35..59	CDD:320139	4/28 (14%)
		TM helix 2	67..88	CDD:320139	3/23 (13%)
		TM helix 3	103..126	CDD:320139	6/36 (17%)
		TM helix 4	148..164	CDD:320139	5/15 (33%)
		TM helix 5	193..216	CDD:320139	4/22 (18%)
		TM helix 6	299..321	CDD:320139	5/21 (24%)
		TM helix 7	331..356	CDD:320139	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100