DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstC-R2 and cxcr4

DIOPT Version :9

Sequence 1:	NP_001303398.1	Gene:	AstC-R2 / 40019	FlyBaseID:	FBgn0036789	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001090831.1	Gene:	cxcr4 / 100038176	XenbaseID:	XB-GENE-489917	Length:	358	Species:	Xenopus tropicalis

Alignment Length:	328	Identity:	97/328 - (29%)
Similarity:	164/328 - (50%)	Gaps:	28/328 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 QNGSHYLEYDDDGPDC----SYSYNFILKLITMILYALVCIIGLFGNTLVIYVVMRFSKMQTVTN 181
            :|||.  :::|....|    :..:|   ::....:|:.:.::|:.||.||:.|:....|.:|:|:
Frog    19 ENGSG--DFEDFSEPCFMHDNSDFN---RIFLPTIYSFIFLLGIIGNGLVVVVMGYQKKSRTMTD 78

  Fly   182 IYILNLAIADECFLIGIPFLLYTMQVGNWPFGNYMCKAYMVSTSITSFTSSIFLLIMSADRYIAV 246
            .|.|:|::||..|:..:||......:| |.|..::|||..|..::..::|.:.|..:|.|||:|:
Frog    79 KYRLHLSVADLLFVFTLPFWSVDAAIG-WYFKEFLCKAVHVIYTVNLYSSVLILAFISLDRYLAI 142

  Fly   247 CHPISSPRYRTPFVSKLVSAFAWMTSVLLMLPVILFASTVQSSNGNVSCNIEWP-DTQNSHTDST 310
            .|..:|...|.....|:|.|..|:.::||.:|.::|| .|...||...|:..:| |.:.:.|..
Frog   143 VHATNSQGSRKMLADKVVYAGVWLPALLLTVPDLVFA-RVSDENGQFVCDRIYPIDNRETWTVG- 205

  Fly   311 FILYSLVLGFATPLTFILVFYCLVIRKLHTVGPKHKSKEKKRSHRKVTKLVLTVISAYIFCWLPH 375
            |....:.:|...|...||:.||::|.||        |..|....||..|..:.:|.|:..||||:
Frog   206 FRFLHITVGLILPGLIILICYCVIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPY 262

  Fly   376 WI----SQVALISSAPQRC--ASRLELAVFLACGCLSYSNSAMNPILYAFLSDNFKKSFMKACTC 434
            ::    ....|:......|  .:.|..|:.:. ..|::.:..:||||||||...||.|...|.|.
Frog   263 YVCLTTDTFMLLGLLKADCIWENTLHKAISIT-EALAFFHCCLNPILYAFLGAKFKTSAQNAFTS 326

  Fly   435 AAR 437
            .:|
Frog   327 VSR 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstC-R2	NP_001303398.1	7tm_4	156..>372	CDD:304433	67/216 (31%)
AstC-R2	NP_001303398.1	7tm_1	162..417	CDD:278431	78/261 (30%)
cxcr4	NP_001090831.1	Important for chemokine binding and signaling. /evidence=ECO:0000250	1..25		3/7 (43%)
		CXCR4_N	10..42	CDD:371902	6/27 (22%)
		7tmA_CXCR4	43..320	CDD:341334	87/288 (30%)
		TM helix 1	43..70	CDD:341334	7/26 (27%)
		TM helix 2	77..102	CDD:341334	9/24 (38%)
		Chemokine binding. /evidence=ECO:0000250	98..101		0/2 (0%)
		TM helix 3	113..143	CDD:341334	11/29 (38%)
		Chemokine binding. /evidence=ECO:0000250	117..121		1/3 (33%)
		Involved in dimerization, when bound to chemokine. /evidence=ECO:0000250	139..151		4/11 (36%)
		TM helix 4	155..177	CDD:341334	7/21 (33%)
		Chemokine binding, important for signaling. /evidence=ECO:0000250	190..194		1/3 (33%)
		TM helix 5	203..232	CDD:341334	9/29 (31%)
		TM helix 6	239..269	CDD:341334	9/29 (31%)
		TM helix 7	288..313	CDD:341334	9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910