DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4306 and GGCT

DIOPT Version :9

Sequence 1:	NP_649038.1	Gene:	CG4306 / 40017	FlyBaseID:	FBgn0036787	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_076956.1	Gene:	GGCT / 79017	HGNCID:	21705	Length:	188	Species:	Homo sapiens

Alignment Length:	208	Identity:	72/208 - (34%)
Similarity:	109/208 - (52%)	Gaps:	33/208 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LPKGNCHSISGLNSTLNLPEIRGDQFLYFGFGSNMLIKRIHIQNPSAVRIGPALLPDYRLDFALE 81
            :....|..::|.:.         :.||||.:|||:|.:|||::||||.....|.|.|::|||. .
Human     1 MANSGCKDVTGPDE---------ESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFG-N 55

  Fly    82 SAG-----WSGSVATIVPTQGDHVWGTLWKIDLSNLPDIDSQEGVSQGIYEPRTVYVKLHGESES 141
            |.|     |.|.:|||..:.||.|||.:||::.|||..:|.||||..|:|....|.|... |.:.
Human    56 SQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQ-EGKE 119

  Fly   142 TPARAYLLTKQPESNLYELPKDSIPLSRQPSKTYLQCLVKGAIESSVPEDYVQRLRSIKHN---G 203
            ...|:||:|.      ||        |..||..|.:.:..||.|:.:|.:|.::|::|:.|   |
Human   120 ITCRSYLMTN------YE--------SAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTG 170

  Fly   204 QVNSYLERKLELG 216
            :|:..:|..::.|
Human   171 KVSEEIEDIIKKG 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4306	NP_649038.1	AIG2_2	99..196	CDD:290488	33/96 (34%)
GGCT	NP_076956.1	Substrate binding. /evidence=ECO:0000305\|PubMed:18515354	19..24		2/4 (50%)
GGCT	NP_076956.1	AIG2_2	78..160	CDD:372719	33/96 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147197
Domainoid	1	1.000	62	1.000	Domainoid score	I10350
eggNOG	1	0.900	-	-		E1_KOG4059
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11437
Inparanoid	1	1.050	116	1.000	Inparanoid score	I4823
Isobase	1	0.950	-	0	Normalized mean entropy	S4447
OMA	1	1.010	-	-		QHG63765
OrthoDB	1	1.010	-	-		D1484710at2759
OrthoFinder	1	1.000	-	-		FOG0003477
OrthoInspector	1	1.000	-	-		otm40775
orthoMCL	1	0.900	-	-		OOG6_105402
Panther	1	1.100	-	-	O	PTHR12935
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3715
SonicParanoid	1	1.000	-	-		X2366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750