Protein Alignment CG5103 and TKL1

DIOPT Version :9

• Sequence 1: NP_649036.1
• Gene: CG5103 / 40012
• FlyBaseID: FBgn0036784
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_015399.1
• Gene: TKL1 / 856188
• SGDID: S000006278
• Length: 680
• Species: Saccharomyces cerevisiae
• Alignment Length: 611
• Identity: 176/611 - (28%)
• Similarity: 269/611 - (44%)
• Gaps: 104/611 - (17%)

  Fly    21 LRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSSDRLVLSKGHAAPILYAVW 85
            :||.::.:...|.||||.:...:|....|| :.|||:|..:|...:.||.|||.|||..:||::.
Yeast    15 IRILAVDTVSKANSGHPGAPLGMAPAAHVL-WSQMRMNPTNPDWINRDRFVLSNGHAVALLYSML 78

  Fly    86 AEAGL-FPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAAGMAYVGKHL-------- 141
            ...|. ..:|:|:..|::.|...|||...|..|:|:||.||||||.|.|||....:|
Yeast    79 HLTGYDLSIEDLKQFRQLGSRTPGHPEFELPGVEVTTGPLGQGISNAVGMAMAQANLAATYNKPG 143

  Fly   142 -DKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKIF---CSDIGTEMEVYRERL 202
             ..:|..|||.:|||...||...|:...|||..|.||..|:|.|||.   .:.|..:.:| .:|.
Yeast   144 FTLSDNYTYVFLGDGCLQEGISSEASSLAGHLKLGNLIAIYDDNKITIDGATSISFDEDV-AKRY 207

  Fly   203 DAFGFNAL-VLNGH-DIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGIEEMHAQPLGKRA 265
            :|:|:..| |.||: |:..:|||...|..:|.|||.:...||.|...|. .|...:|..||  :|
Yeast   208 EAYGWEVLYVENGNEDLAGIAKAIAQAKLSKDKPTLIKMTTTIGYGSLH-AGSHSVHGAPL--KA 269

  Fly   266 ESAIKHLQMKIA-NPNVR-LTPKKV----GKCGHAPEVHINNIMLCSPPNYR-----LGDSVAPR 319
            :. :|.|:.|.. ||:.. :.|::|    .|....|.|..||........|:     ||..:|.|
Yeast   270 DD-VKQLKSKFGFNPDKSFVVPQEVYDHYQKTILKPGVEANNKWNKLFSEYQKKFPELGAELARR 333

  Fly   320 LAYGTALAKIAADNPRVIALDGDTK----NSTYADKMRNAFPE---------------------- 358
            |: |...|...:..|...|.|....    :.|..:.:.|..||
Yeast   334 LS-GQLPANWESKLPTYTAKDSAVATRKLSETVLEDVYNQLPELIGGSADLTPSNLTRWKEALDF 397

  Fly   359 ------------RFIECFTAQQNLVGV------AVGATCRRRTVAFVSTYATFFTRAFDQIRMGA 405
                        |:|. :..:::.:|.      |.||..:    .:..|:..|.:.|...:|:.|
Yeast   398 QPPSSGSGNYSGRYIR-YGIREHAMGAIMNGISAFGANYK----PYGGTFLNFVSYAAGAVRLSA 457

  Fly   406 ISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVFYPTDAVSTERAVELAANTKGVCY 470
            :|...|.:..:|....:|||||:...:|.:|.|||:|...|:.|.|......|.:.:..:|..
Yeast   458 LSGHPVIWVATHDSIGVGEDGPTHQPIETLAHFRSLPNIQVWRPADGNEVSAAYKNSLESKHT-- 520

  Fly   471 IRTTYPSTTVIYNND---------EVFAVGLGKVVRQKPSDEVLLIGAGVTLYECLAAAERLEED 526
                 ||...:...:         |..:.| |.|::...:.:::|:..|..:...:.||:.|...
Yeast   521 -----PSIIALSRQNLPQLEGSSIESASKG-GYVLQDVANPDIILVATGSEVSLSVEAAKTLAAK 579

  Fly   527 CITARVI---DPFTV--KPLDVGLIV 547
            .|.|||:   |.||.  :||:..|.|
Yeast   580 NIKARVVSLPDFFTFDKQPLEYRLSV 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	176/611 (29%)
		TPP_TK	19..263	CDD:238970	96/256 (38%)
		TPP_PYR_DXS_TK_like	321..474	CDD:132916	39/196 (20%)
		Transketolase_C	493..613	CDD:280875	18/60 (30%)
TKL1	NP_015399.1	tktlase_bact	9..664	CDD:272974	176/611 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I1168
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I994
Isobase	1	0.950	-	0	Normalized mean entropy	S1450
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		mtm9238
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1527
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.700