Protein Alignment CG5103 and Tktl1

DIOPT Version :10

• Sequence 1: NP_649036.1
• Gene: CG5103 / 40012
• FlyBaseID: FBgn0036784
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_113556.2
• Gene: Tktl1 / 83553
• MGIID: 1933244
• Length: 595
• Species: Mus musculus
• Alignment Length: 623
• Identity: 277/623 - (44%)
• Similarity: 386/623 - (61%)
• Gaps: 46/623 - (7%)

  Fly     3 NAKLDSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSS 67
            ||..|.|.:|.|:|:|.:|||.||.:|.::.:.:...|:: ||||:||||..||...:.|.:|.:
Mouse    13 NAGPDEKTLQVLRDMANRLRIRSIKATNSSTTSYLIPCSN-AEIMSVLFFYTMRYKQEDPENPDN 76

  Fly    68 DRLVLSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAA 132
            ||.:||||                                      |.||:|:||..|||:..|.
Mouse    77 DRCILSKG--------------------------------------LPFVNVATGWPGQGLGAAC 103

  Fly   133 GMAYVGKHLDKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKI-FCSDIGTE-- 194
            ||||.||:.|:|.||.:.::||.|:|||:|||:..||.:|.||||..|||:|:| ..|.:..|
Mouse   104 GMAYTGKYFDQASYRVFCLLGDEESTEGSVWEAFAFASYYNLDNLMAIFDVNRIGHSSSMSVEHC 168

  Fly   195 MEVYRERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGIEEMHAQ 259
            :.:|::|.:|||:|..|::|.|:..|...|..||..:|||||::|:|.|.:....:|..|..:.:
Mouse   169 IAIYQKRCEAFGWNTYVVDGRDVKTLCHVFSQAAQVRGKPTAVVAKTFKARGMPNVEDAESWYGR 233

  Fly   260 PLGK-RAESAIKHLQMKIANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSVAPRLAYG 323
            |:.| ||::.:|.::.:| ..|..|.|..  ....:|:::|.||.:.|||.|...|.|:.:.|.|
Mouse   234 PMPKERADAIVKLIESQI-QTNKILVPSP--PIEDSPQINIMNICMTSPPVYVADDKVSTQRACG 295

  Fly   324 TALAKIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRRRTVAFVS 388
            .||||:..:|.|||.|..||||..::|..:...|||||:|..|:||:|.||:|.:.|.||:.|..
Mouse   296 LALAKLGHENDRVIVLGSDTKNCNFSDIFKKEHPERFIQCCIAEQNMVNVALGCSTRDRTIVFAY 360

  Fly   389 TYATFFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVFYPTDAV 453
            ::|.||||||||||:||||..|:|..|.|||.|.|:|.|..|.|||:||||:||...||||:|||
Mouse   361 SFAAFFTRAFDQIRLGAISQININLIGCHCGVSTGDDNPYHMALEDLAMFRAIPNCVVFYPSDAV 425

  Fly   454 STERAVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGVTLYECLA 518
            |||.||.||||||.:|:|||:...|.:||...|.|.:|..||||...:|:|::|||||||:|.|.
Mouse   426 STEHAVYLAANTKEMCFIRTSQAETAIIYTTQETFQIGQAKVVRHSDNDKVIVIGAGVTLHEALV 490

  Fly   519 AAERLEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSALADYRNF 583
            ||..|.::.|:.||||.||:||||:..|:.:.|...|||:.|||||.:||:|.||.:|::...|.
Mouse   491 AAAELSKEDISIRVIDLFTIKPLDIATIISNAKATGGRIITVEDHYPEGGIGGAVCAAVSMEPNI 555

  Fly   584 VVKHLYITTVPRSGPPAVLLDMFGVSSRNIYKASLAIM 621
            ||.:|.:..|||||.....||..|:|||:|..|...|:
Mouse   556 VVHNLAVMDVPRSGRCNEALDFSGISSRHIIVAVKCIL 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	272/612 (44%)
Tktl1	NP_113556.2	PRK05899	17..590	CDD:235639	274/614 (45%)