DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5103 and TKTL1

DIOPT Version :9

Sequence 1:	NP_649036.1	Gene:	CG5103 / 40012	FlyBaseID:	FBgn0036784	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_036385.3	Gene:	TKTL1 / 8277	HGNCID:	11835	Length:	596	Species:	Homo sapiens

Alignment Length:	617	Identity:	297/617 - (48%)
Similarity:	405/617 - (65%)	Gaps:	45/617 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKLDSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSSD 68
            |:.|...:|.|:|:|.:||||||.:|.:..|||||||:|.:|||:||||..||.....|.:|.:|
Human    14 ARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDND 78

  Fly    69 RLVLSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAAG 133
            |.||:|                                      |||||||:||.||||:.||.|
Human    79 RFVLAK--------------------------------------RLSFVDVATGWLGQGLGVACG 105

  Fly   134 MAYVGKHLDKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKIFCSD-IGTE--M 195
            |||.||:.|:|.||.:.::.|||::||:|||::.||.:|.||||..|||:|::..|. :..|  :
Human   106 MAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCI 170

  Fly   196 EVYRERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGIEEMHAQP 260
            .:|:.|.:|||:|..|::|.|::.|.:.|..|:..|.||||::|:|.||:....||..|..||:|
Human   171 NIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKP 235

  Fly   261 LGK-RAESAIKHLQMKIANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSVAPRLAYGT 324
            :.: ||::.||.::.:|.... .|.|:.  ....:|||:|.::.:.|||:||:||.:|.|.|.|.
Human   236 MPRERADAIIKLIESQIQTSR-NLDPQP--PIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGL 297

  Fly   325 ALAKIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRRRTVAFVST 389
            ||||:...|.||:.|||||:.||:::.....:||||||||.|:||:|.||:|...|.||:||.||
Human   298 ALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFAST 362

  Fly   390 YATFFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVFYPTDAVS 454
            :|.|.|||||.||:|.::.:|:|..|||||.|:|:||.|||.|||:||||:||..|:||||||||
Human   363 FAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVS 427

  Fly   455 TERAVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGVTLYECLAA 519
            ||.||.||||.||:|:||||.|.|.|||...|.|.:|..||:|...||:|.:||||:|:||.|||
Human   428 TEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAA 492

  Fly   520 AERLEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSALADYRNFV 584
            |:.|.:..|..||||.||:|||||..||...|...|||:.|||||.|||:||||.:|::...:..
Human   493 ADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQ 557

  Fly   585 VKHLYITTVPRSGPPAVLLDMFGVSSRNIYKA 616
            |..|.::.||:||....||||:|:|:|:|..|
Human   558 VHSLAVSGVPQSGKSEELLDMYGISARHIIVA 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	295/609 (48%)
		TPP_TK	19..263	CDD:238970	104/246 (42%)
		TPP_PYR_DXS_TK_like	321..474	CDD:132916	93/152 (61%)
		Transketolase_C	493..613	CDD:280875	62/119 (52%)
TKTL1	NP_036385.3	PRK05899	17..594	CDD:235639	296/614 (48%)
		TPP_enzymes	30..245	CDD:294952	106/252 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..277		6/23 (26%)
		TPP_PYR_DXS_TK_like	293..448	CDD:132916	94/154 (61%)
		Transketolase_C	464..586	CDD:280875	63/121 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142507
Domainoid	1	1.000	136	1.000	Domainoid score	I4919
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58668
OrthoDB	1	1.010	-	-		D159833at33208
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	1	1.100	-	-	O	PTHR43195
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720