Protein Alignment CG5103 and Tktl2

DIOPT Version :9

• Sequence 1: NP_649036.1
• Gene: CG5103 / 40012
• FlyBaseID: FBgn0036784
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001258503.1
• Gene: Tktl2 / 74419
• MGIID: 1921669
• Length: 627
• Species: Mus musculus
• Alignment Length: 620
• Identity: 354/620 - (57%)
• Similarity: 442/620 - (71%)
• Gaps: 11/620 - (1%)

  Fly     3 NAKLDSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSS 67
            :|||:|...|.|:|||.:||||||.:|.|..|||||||.|:||||.||||..||.....|..|.:
Mouse     6 DAKLESDTFQVLQDVANRLRIHSIRATCACSSGHPTSCCSVAEIMAVLFFHTMRYKQADPEHPDN 70

  Fly    68 DRLVLSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAA 132
            ||.|||||||||||||||.|.|.....:|.||||:..|||||||||||||||:|||||||:..|.
Mouse    71 DRFVLSKGHAAPILYAVWVEVGRICESDLLNLRKIHCDLEGHPTPRLSFVDVATGSLGQGLGAAC 135

  Fly   133 GMAYVGKHLDKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKIFCSDIGTE--- 194
            ||||.||:.|||.||.:.::||||::||:|||:|.||.||.||||..|||:|::  ...||.
Mouse   136 GMAYTGKYFDKASYRVFCLMGDGESSEGSVWEALAFASHYNLDNLVAIFDVNRL--GQSGTAPLE 198

  Fly   195 --MEVYRERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGIEEMH 257
              ..||.:|..|||:|..|::|||::.|.:||..||..|.|||||:|:|.||:....:|..|..|
Mouse   199 HCTAVYEKRCQAFGWNTYVVDGHDVEALCQAFWKAAQVKNKPTALIAKTFKGRGIPNVEDAENWH 263

  Fly   258 AQPLGK-RAESAIKHLQMKIANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSVAPRLA 321
            .:|:.| ||:..:|.::.:| ..|..||||.  ....:|.:.::|..:.|.|.|:|||.:|.|.|
Mouse   264 GKPMPKDRADGIVKLIENRI-QTNRNLTPKP--PIEDSPRISMSNTKMTSLPVYKLGDMIATREA 325

  Fly   322 YGTALAKIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRRRTVAF 386
            ||.||||:...|.|||.|||||||||:::..:...||||||||.|:||:|.||:|...|.||:||
Mouse   326 YGLALAKLGQSNQRVIVLDGDTKNSTFSEVFKKEHPERFIECFIAEQNMVSVALGCATRGRTIAF 390

  Fly   387 VSTYATFFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVFYPTD 451
            |||:|.|.|||||||||||||.||:||.|||||.|:||||||||.|||:|||||||..|||||:|
Mouse   391 VSTFAAFLTRAFDQIRMGAISQTNINFVGSHCGVSVGEDGPSQMALEDLAMFRSIPNCTVFYPSD 455

  Fly   452 AVSTERAVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGVTLYEC 516
            |||||.||.|||||||:|:||||.|.|.|||..:|.|.:|..||:||...|:|.:|||||||:|.
Mouse   456 AVSTEHAVYLAANTKGMCFIRTTRPKTAVIYTAEENFVIGQAKVIRQSAVDKVTVIGAGVTLHEA 520

  Fly   517 LAAAERLEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSALADYR 581
            |.|||.|.:..|..||||.||:||||...|::..|...|:|:.|||||::||:||||.:|::...
Mouse   521 LVAAEELSQQGIFIRVIDLFTIKPLDAVTIIQSAKATGGQIITVEDHYREGGIGEAVCAAISREP 585

  Fly   582 NFVVKHLYITTVPRSGPPAVLLDMFGVSSRNIYKA 616
            :.||:.|.:|.|||||.|:.||||||:|:|:|..|
Mouse   586 DIVVRQLAVTEVPRSGKPSELLDMFGISARHIIAA 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	350/611 (57%)
		TPP_TK	19..263	CDD:238970	140/248 (56%)
		TPP_PYR_DXS_TK_like	321..474	CDD:132916	109/152 (72%)
		Transketolase_C	493..613	CDD:280875	64/119 (54%)
Tktl2	NP_001258503.1	PRK05899	17..623	CDD:235639	349/609 (57%)
		TPP_TK	22..270	CDD:238970	140/249 (56%)
		TPP_PYR_DXS_TK_like	324..479	CDD:132916	110/154 (71%)
		Transketolase_C	495..617	CDD:280875	65/121 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	338	1.000	Domainoid score	I1103
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	782	1.000	Inparanoid score	I523
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58668
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		mtm8851
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	1	1.100	-	-	O	PTHR43195
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1527
SonicParanoid	1	1.000	-	-		X1857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860