Protein Alignment CG5103 and Tktl1

DIOPT Version :10

• Sequence 1: NP_649036.1
• Gene: CG5103 / 40012
• FlyBaseID: FBgn0036784
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001103004.1
• Gene: Tktl1 / 689374
• RGDID: 1593490
• Length: 596
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 275/619 - (44%)
• Similarity: 385/619 - (62%)
• Gaps: 45/619 - (7%)

  Fly     7 DSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSSDRLV 71
            |.|.:|.|:|:|.:|||..|.:|.::.:.:.|.|:|.||||:||||..||...:.|.:|.:||.:
  Rat    17 DEKTLQVLRDMANRLRIRFIRTTSSSTTSYLTPCSSAAEIMSVLFFYTMRYKQEDPENPDNDRCI 81

  Fly    72 LSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAAGMAY 136
            ||||                                      :.||.|:||..|||:..|.||||
  Rat    82 LSKG--------------------------------------IPFVKVATGWPGQGLGAARGMAY 108

  Fly   137 VGKHLDKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKI-FCSDIGTE--MEVY 198
            .||:.|:|.||.:.::||.|:|||:|||:..||.:|.||||..|||:|:| ..|.:..|  :.:|
  Rat   109 TGKYFDQASYRVFCLLGDEESTEGSVWEAFAFASYYNLDNLMAIFDVNRIGHSSSMSVEHCVGIY 173

  Fly   199 RERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGIEEMHAQPLGK 263
            ::|.:|||:|..|::|.:::.|.:.|..||..:|||||::|:|.|.:....:|..|..|.:|:.|
  Rat   174 QKRCEAFGWNTYVVDGRNVETLCRVFSQAAQVRGKPTAVVAKTFKARGMPNVEDAESWHGRPMPK 238

  Fly   264 -RAESAIKHLQMKIANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSVAPRLAYGTALA 327
             ||::.||.::.:|.: |..|.|..  ...::|:::|.:|.:.|||.|...|.|:.:.|.|.|||
  Rat   239 ERADAIIKLIESQIQS-NKILVPSP--PIENSPQINIMDIHMASPPAYVADDMVSTQRACGLALA 300

  Fly   328 KIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRRRTVAFVSTYAT 392
            |:..:|.|||.||.||:|..::|..:...|||||:|:.|:||:|.||:|...|.|.:||..|:|.
  Rat   301 KLGHENDRVIVLDSDTENCNFSDIFKKEHPERFIQCYIAEQNMVNVALGCATRDRIIAFACTFAA 365

  Fly   393 FFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVFYPTDAVSTER 457
            ||||||||||:||||..|:|..|.|||.|.|:|.|..|.|||:||||:||...||||:||||||.
  Rat   366 FFTRAFDQIRVGAISQININLIGCHCGVSTGDDNPYHMALEDLAMFRAIPNCIVFYPSDAVSTEH 430

  Fly   458 AVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGVTLYECLAAAER 522
            |:.||||||.:|:|.|:...|.:||...|.|.:|..||||....|:|::|||||||:|.|.||:.
  Rat   431 AIYLAANTKEMCFIHTSQAETAIIYTTQETFEIGQAKVVRHSNDDKVIVIGAGVTLHEALVAADE 495

  Fly   523 LEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSALADYRNFVVKH 587
            |.::.|:.||||.||:||||...|:.:.|...||||.|||||.:||:|.||.:|::...|.||..
  Rat   496 LSKEDISIRVIDLFTIKPLDSATIISNAKATGGRIVTVEDHYLEGGIGGAVCAAVSMEPNIVVHR 560

  Fly   588 LYITTVPRSGPPAVLLDMFGVSSRNIYKASLAIM 621
            |.:..|||||.....||..|:|||:|..|...|:
  Rat   561 LAVMDVPRSGRCNEALDFSGISSRHIIVAVKCIL 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	272/612 (44%)
Tktl1	NP_001103004.1	PRK05899	52..591	CDD:235639	261/579 (45%)