Protein Alignment CG5103 and Tktl1

DIOPT Version :9

• Sequence 1: NP_649036.1
• Gene: CG5103 / 40012
• FlyBaseID: FBgn0036784
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001103004.1
• Gene: Tktl1 / 689374
• RGDID: 1593490
• Length: 596
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 275/619 - (44%)
• Similarity: 385/619 - (62%)
• Gaps: 45/619 - (7%)

  Fly     7 DSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSSDRLV 71
            |.|.:|.|:|:|.:|||..|.:|.::.:.:.|.|:|.||||:||||..||...:.|.:|.:||.:
  Rat    17 DEKTLQVLRDMANRLRIRFIRTTSSSTTSYLTPCSSAAEIMSVLFFYTMRYKQEDPENPDNDRCI 81

  Fly    72 LSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAAGMAY 136
            ||||                                      :.||.|:||..|||:..|.||||
  Rat    82 LSKG--------------------------------------IPFVKVATGWPGQGLGAARGMAY 108

  Fly   137 VGKHLDKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKI-FCSDIGTE--MEVY 198
            .||:.|:|.||.:.::||.|:|||:|||:..||.:|.||||..|||:|:| ..|.:..|  :.:|
  Rat   109 TGKYFDQASYRVFCLLGDEESTEGSVWEAFAFASYYNLDNLMAIFDVNRIGHSSSMSVEHCVGIY 173

  Fly   199 RERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGIEEMHAQPLGK 263
            ::|.:|||:|..|::|.:::.|.:.|..||..:|||||::|:|.|.:....:|..|..|.:|:.|
  Rat   174 QKRCEAFGWNTYVVDGRNVETLCRVFSQAAQVRGKPTAVVAKTFKARGMPNVEDAESWHGRPMPK 238

  Fly   264 -RAESAIKHLQMKIANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSVAPRLAYGTALA 327
             ||::.||.::.:|.: |..|.|..  ...::|:::|.:|.:.|||.|...|.|:.:.|.|.|||
  Rat   239 ERADAIIKLIESQIQS-NKILVPSP--PIENSPQINIMDIHMASPPAYVADDMVSTQRACGLALA 300

  Fly   328 KIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRRRTVAFVSTYAT 392
            |:..:|.|||.||.||:|..::|..:...|||||:|:.|:||:|.||:|...|.|.:||..|:|.
  Rat   301 KLGHENDRVIVLDSDTENCNFSDIFKKEHPERFIQCYIAEQNMVNVALGCATRDRIIAFACTFAA 365

  Fly   393 FFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVFYPTDAVSTER 457
            ||||||||||:||||..|:|..|.|||.|.|:|.|..|.|||:||||:||...||||:||||||.
  Rat   366 FFTRAFDQIRVGAISQININLIGCHCGVSTGDDNPYHMALEDLAMFRAIPNCIVFYPSDAVSTEH 430

  Fly   458 AVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGVTLYECLAAAER 522
            |:.||||||.:|:|.|:...|.:||...|.|.:|..||||....|:|::|||||||:|.|.||:.
  Rat   431 AIYLAANTKEMCFIHTSQAETAIIYTTQETFEIGQAKVVRHSNDDKVIVIGAGVTLHEALVAADE 495

  Fly   523 LEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSALADYRNFVVKH 587
            |.::.|:.||||.||:||||...|:.:.|...||||.|||||.:||:|.||.:|::...|.||..
  Rat   496 LSKEDISIRVIDLFTIKPLDSATIISNAKATGGRIVTVEDHYLEGGIGGAVCAAVSMEPNIVVHR 560

  Fly   588 LYITTVPRSGPPAVLLDMFGVSSRNIYKASLAIM 621
            |.:..|||||.....||..|:|||:|..|...|:
  Rat   561 LAVMDVPRSGRCNEALDFSGISSRHIIVAVKCIL 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	272/612 (44%)
		TPP_TK	19..263	CDD:238970	92/246 (37%)
		TPP_PYR_DXS_TK_like	321..474	CDD:132916	88/152 (58%)
		Transketolase_C	493..613	CDD:280875	61/119 (51%)
Tktl1	NP_001103004.1	TPP_enzymes	29..245	CDD:294952	95/253 (38%)
		PRK05899	52..591	CDD:235639	261/579 (45%)
		TPP_PYR_DXS_TK_like	294..447	CDD:132916	88/152 (58%)
		Transketolase_C	464..586	CDD:280875	62/121 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336014
Domainoid	1	1.000	147	1.000	Domainoid score	I4383
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I487
OMA	1	1.010	-	-		QHG58668
OrthoDB	1	1.010	-	-		D159833at33208
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	1	1.100	-	-	O	PTHR43195
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1857
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910