DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5103 and Tkt

DIOPT Version :9

Sequence 1:	NP_649036.1	Gene:	CG5103 / 40012	FlyBaseID:	FBgn0036784	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_072114.2	Gene:	Tkt / 64524	RGDID:	621036	Length:	655	Species:	Rattus norvegicus

Alignment Length:	624	Identity:	342/624 - (54%)
Similarity:	446/624 - (71%)	Gaps:	12/624 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLDSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSSDR 69
            |.|.:.:|.|||.|.:|||.||.:|.||.|||||||.|.||||.||||..||.....||:|.:||
  Rat    38 KPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKALDPRNPHNDR 102

  Fly    70 LVLSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAAGM 134
            .|||||||||||||||||||..|..||.||||:.|||:|||.|:.:|.||:|||||||:..|.||
  Rat   103 FVLSKGHAAPILYAVWAEAGFLPEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGM 167

  Fly   135 AYVGKHLDKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKIFCSD---IGTEME 196
            ||.||:.|||.||.|.::||||.:||:|||::.|||.|.||||..|||:|::..||   :..:::
  Rat   168 AYTGKYFDKASYRVYCMLGDGEVSEGSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVD 232

  Fly   197 VYRERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGIEEMHAQPL 261
            ||::|.:|||::|::::||.::||.|||   ...|.:|||::|:|.||:...|||..|..|.:||
  Rat   233 VYQKRCEAFGWHAIIVDGHSVEELCKAF---GQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPL 294

  Fly   262 GKR-AESAIKHLQMKI-ANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSVAPRLAYGT 324
            .|. ||..|:.:..:: :...:..||.:    ..||.|.|.||.:.:||||::||.:|.|.|||.
  Rat   295 PKNMAEQIIQEIYSQVQSKKKILATPPQ----EDAPSVDIANIRMPTPPNYKVGDKIATRKAYGL 355

  Fly   325 ALAKIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRRRTVAFVST 389
            ||||:...:.|:|||||||||||:::..:...|:|||||:.|:||:|.:|||...|.|||.|.||
  Rat   356 ALAKLGHASDRIIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCST 420

  Fly   390 YATFFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVFYPTDAVS 454
            :|.|||||||||||.|||.:|:|..|||||.||||||||||.|||:|||||:|.||||||:|.|:
  Rat   421 FAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVA 485

  Fly   455 TERAVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGVTLYECLAA 519
            ||:||||||||||:|:|||:.|...:||:|:|.|.||..|||.:...|:|.:|||||||:|.|||
  Rat   486 TEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAA 550

  Fly   520 AERLEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSALADYRNFV 584
            ||.|:::.|..||:||||:||||..||:...:..:|||:.|||||.:||:||||.:|:.......
  Rat   551 AEMLKKEKIGVRVLDPFTIKPLDKKLILDCARATKGRILTVEDHYYEGGIGEAVSAAVVGEPGVT 615

  Fly   585 VKHLYITTVPRSGPPAVLLDMFGVSSRNIYKASLAIMKK 623
            |..|.::.|||||.||.||.|||:....|.:|...::.|
  Rat   616 VTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLVTK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	339/613 (55%)
		TPP_TK	19..263	CDD:238970	139/246 (57%)
		TPP_PYR_DXS_TK_like	321..474	CDD:132916	103/152 (68%)
		Transketolase_C	493..613	CDD:280875	61/119 (51%)
Tkt	NP_072114.2	PRK05899	40..652	CDD:235639	340/618 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I487
OMA	1	1.010	-	-		QHG58668
OrthoDB	1	1.010	-	-		D159833at33208
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		mtm9097
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	1	1.100	-	-	O	PTHR43195
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1857
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840