Protein Alignment CG5103 and Tktl2

DIOPT Version :9

• Sequence 1: NP_649036.1
• Gene: CG5103 / 40012
• FlyBaseID: FBgn0036784
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001099550.1
• Gene: Tktl2 / 290685
• RGDID: 1304767
• Length: 627
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 351/624 - (56%)
• Similarity: 442/624 - (70%)
• Gaps: 19/624 - (3%)

  Fly     3 NAKLDSKVVQNLKDVAQKLRIHSITSTQAAKSGHPTSCASLAEIMTVLFFQQMRLNLKHPRDPSS 67
            :|||:|.:.|.|:|||.:||||||.:|.|:.|||||||.|.||||.||||..||.....|..|.:
  Rat     6 DAKLESDIFQALQDVANRLRIHSIRATCASSSGHPTSCCSAAEIMAVLFFHTMRYKQADPEHPDN 70

  Fly    68 DRLVLSKGHAAPILYAVWAEAGLFPVEELRNLRKVDSDLEGHPTPRLSFVDVSTGSLGQGISVAA 132
            ||.|||||||||||||||.|.|.....:|.||||:..|||||||||||||||:|||||||:..|.
  Rat    71 DRFVLSKGHAAPILYAVWVEVGRICESDLLNLRKIHCDLEGHPTPRLSFVDVATGSLGQGLGAAC 135

  Fly   133 GMAYVGKHLDKADYRTYVIVGDGEATEGAVWESLHFAGHYCLDNLCVIFDMNKI---------FC 188
            ||||.||:.|||.||.:.::||||::||:|||:|.||.||.||||..|||:|::         .|
  Rat   136 GMAYTGKYFDKASYRVFCLMGDGESSEGSVWEALAFASHYKLDNLLAIFDVNRLGQSGTAPLEHC 200

  Fly   189 SDIGTEMEVYRERLDAFGFNALVLNGHDIDELAKAFINAASTKGKPTALLARTTKGKDFLGIEGI 253
            :||      |..|..|||:|..|::|||::.|.:||..||..|.|||||:|:|.||:....:|..
  Rat   201 TDI------YETRCQAFGWNTYVVDGHDVEALCQAFWKAAQVKNKPTALIAKTFKGRGIPNVEDA 259

  Fly   254 EEMHAQPLGK-RAESAIKHLQMKIANPNVRLTPKKVGKCGHAPEVHINNIMLCSPPNYRLGDSVA 317
            |..|.:|:.| |.:..:|.::.:| ..|..||||.  ....:|.:.|:|..:.|.|.|:|||.:|
  Rat   260 ENWHGKPMPKDRVDGIVKLIESQI-QTNRNLTPKP--PVEDSPRISISNTKMTSLPAYKLGDMIA 321

  Fly   318 PRLAYGTALAKIAADNPRVIALDGDTKNSTYADKMRNAFPERFIECFTAQQNLVGVAVGATCRRR 382
            .|.|||.||||:...|.|||.|||||||||:::..:...||||||||.|:||:|.||:|...|.|
  Rat   322 TREAYGVALAKLGHSNQRVIVLDGDTKNSTFSEVFKKEHPERFIECFIAEQNMVSVALGCATRGR 386

  Fly   383 TVAFVSTYATFFTRAFDQIRMGAISHTNVNFAGSHCGCSIGEDGPSQMGLEDMAMFRSIPGSTVF 447
            |:|||||:|.|.|||||||||||||.|||||.|||||.||||||||||.|||:|||||||..|:|
  Rat   387 TIAFVSTFAAFLTRAFDQIRMGAISQTNVNFVGSHCGVSIGEDGPSQMALEDLAMFRSIPNCTIF 451

  Fly   448 YPTDAVSTERAVELAANTKGVCYIRTTYPSTTVIYNNDEVFAVGLGKVVRQKPSDEVLLIGAGVT 512
            ||:||||||.|:.|||||||:|:||||.|...|||.::|.|.:|..||:|....|:|.::|||||
  Rat   452 YPSDAVSTEHAIYLAANTKGMCFIRTTRPKLAVIYTSEENFVIGQAKVIRHSADDKVTVVGAGVT 516

  Fly   513 LYECLAAAERLEEDCITARVIDPFTVKPLDVGLIVKHGKLCRGRIVVVEDHYQQGGLGEAVLSAL 577
            |:|.|.||:.|.:..|:.|||||||:||||...|::..|...|:|:.|||||::||:||||.:|:
  Rat   517 LHEALEAADELSQQGISIRVIDPFTIKPLDASTIIQSAKATGGQIITVEDHYREGGIGEAVCAAI 581

  Fly   578 ADYRNFVVKHLYITTVPRSGPPAVLLDMFGVSSRNIYKA 616
            :...:.||..|.:|.|||||.|:.||||||:|:|:|..|
  Rat   582 SREPDIVVHQLAVTEVPRSGKPSELLDMFGISARHIIAA 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5103	NP_649036.1	PRK05899	12..621	CDD:235639	347/615 (56%)
		TPP_TK	19..263	CDD:238970	140/252 (56%)
		TPP_PYR_DXS_TK_like	321..474	CDD:132916	109/152 (72%)
		Transketolase_C	493..613	CDD:280875	62/119 (52%)
Tktl2	NP_001099550.1	PRK05899	17..623	CDD:235639	346/613 (56%)
		TPP_TK	22..272	CDD:238970	141/255 (55%)
		TPP_PYR_DXS_TK_like	324..479	CDD:132916	110/154 (71%)
		Transketolase_C	495..617	CDD:280875	63/121 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I487
OMA	1	1.010	-	-		QHG58668
OrthoDB	1	1.010	-	-		D159833at33208
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		mtm9097
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	1	1.100	-	-	O	PTHR43195
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840