Protein Alignment LMNB1 and LPX2

DIOPT Version :10

• Sequence 1: NP_005564.1
• Gene: LMNB1 / 4001
• HGNCID: 6637
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_012874.1
• Gene: LPX2 / 853816
• SGDID: S000001533
• Length: 922
• Species: Saccharomyces cerevisiae
• Alignment Length: 584
• Identity: 116/584 - (19%)
• Similarity: 226/584 - (38%)
• Gaps: 158/584 - (27%)

Human    23 SPTRLSRLQE--KEELRELNDR---LAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALY 82
            ||..|:..|:  ..:|::::.|   :.::.::..:....|.|||....::||.:...|.|  .|:
Yeast   347 SPVVLNEAQKLANRKLQDIDSRDTYMLLFGNQAYNKLAVNIALQHYSVKQEEKKKIYLGG--GLW 409

Human    83 ET--------------------ELADARRALDDTARERAKL---QIELG----KCKAEHD-QLLL 119
            .|                    |.|..:|.:|.....|:::   :.|.|    :.|.::| ||||
Yeast   410 MTPEEVNAVAKKLISPVVNEIDERASRQRDVDKDIERRSRVLDQEYEDGNSMERAKEQNDGQLLL 474

Human   120 NYAKKESDLNGAQIK---------LREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEA 175
            ..|.|:.....|:..         :::....|..|:..|..|..::::|..:|::      :|..
Yeast   475 AMASKQQQEKEAKKAEEGQRYDQFVQKMNIKLQQKEKELENARENRENLRNELQE------RLSK 533

Human   176 SLAAAKKQLAD-ETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYE 239
            :|:....:|.| ....:.||:|   |..|.....:|.::...|..|...|  |:|..|..|:|.|
Yeast   534 NLSGENDELNDWNDACERDLKN---SSIEHYYAVRSHFDNLGNSERGYDE--LLEERSKIQVEIE 593

Human   240 YKLAQ------ALHEMREQHDA----------QVRLYKEELEQTYHAKLENARLSSEMNTSTVNS 288
            ..:|.      |:|...|..||          ::...|:.|:.|.:..|.   :|:||.......
Yeast   594 RLVASIAEHKTAIHGFGETADAGGAIPAVQKQKIPTRKDLLDATVNDPLV---ISAEMAKEEAEM 655

Human   289 AREELMESRMRIESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQM 353
            |.||.|...::::.:.. :.|:.         ::|.|..|.:||:.::|.           |...
Yeast   656 ATEECMLKELQVDEMII-IRNIM---------LRECEKKLEEEKETAKRS-----------RRGT 699

Human   354 QQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVT-VSRASSSRSVRTTR---- 413
            ::..|:.....||.::                     :|..:.:|| :.:::|.:.|..:|
Yeast   700 EESKNNSNFSRDVIMS---------------------TPDNNEKVTPIGKSASPKDVVKSRFLST 743

Human   414 ---GKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQ--DQPMGGWEMIR 473
               ||    |::.|.::.|:        ||   :..:..||......|...:  |..:..:::.:
Yeast   744 YNTGK----DIDSSASARSI--------TG---VSGVLDDGPKTPTSNKENELIDDEVKSYKVHQ 793

Human   474 KI---GDTSVSYK--YTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILK 532
            .:   |:.|::.|  .:||....:|.::||           ...|..||.:..|..:...|.:|
Yeast   794 AVDGTGEDSIANKRDKSSRPAANSGGSITI-----------EQFLFNKNADKQGLSKTESVTMK 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LMNB1	NP_005564.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		3/7 (43%)
		Head	2..34		4/12 (33%)
		Filament	31..387	CDD:459643	82/414 (20%)
		Coil 1A	35..69		6/36 (17%)
		Linker 1	70..81		2/10 (20%)
		Coil 1B	82..215		33/170 (19%)
		Linker 2	216..243		9/26 (35%)
		Coil 2	244..386		27/157 (17%)
		Tail	387..586		31/161 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..432		11/51 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	415..420		1/4 (25%)
		LTD	439..543	CDD:460003	20/101 (20%)
LPX2	NP_012874.1	Eisosome1	347..466	CDD:432763	23/120 (19%)
		YhaN	396..>603	CDD:443752	48/219 (22%)