DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and ERG5

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_013728.1	Gene:	ERG5 / 855029	SGDID:	S000004617	Length:	538	Species:	Saccharomyces cerevisiae

Alignment Length:	530	Identity:	106/530 - (20%)
Similarity:	190/530 - (35%)	Gaps:	131/530 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHDHRAKLWMGTKL--------YLVDCNPK 90
            ||                ::||.     .|.::....:::|| |....|        ::|..:.:
Yeast    79 WP----------------IIGPF-----LESLDPKFEEYKAK-WASGPLSCVSIFHKFVVIASTR 121

  Fly    91 DIQALCSAQQLLQKTN-------DYRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVA 148
            |:     |:::||.:.       |..|.....|..:|..|.....:|:.:     |....||.:|
Yeast   122 DL-----ARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHTDYRKSL-----NGLFTKQALA 176

  Fly   149 VF-EKQSRILLTNVAKFAESGDQIDF---------LQLISCFTLDTICETALGVSVGSQSSAKSE 203
            .: ....:|:...:.||.....:.::         .:::...:|::.|               ..
Yeast   177 QYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFC---------------GN 226

  Fly   204 YL--DAVKSI-----LVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEI 261
            |:  |.|:.|     ||.....|.|.    ..|...|          ||.:|      :|..|..
Yeast   227 YITEDQVRKIADDYYLVTAALELVNF----PIIIPYT----------KTWYG------KKTADMA 271

  Fly   262 NQDAENRNYQSSDAELDGVKRTLCFLDTLLL-------SKGPDG----KPLTVKDIREEVDTIIF 315
            .:..||....:.|....|.| .:|.:|....       |...|.    :..|.|:|.|.|.|.:|
Yeast   272 MKIFENCAQMAKDHIAAGGK-PVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLF 335

  Fly   316 GGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMY 380
            ...|.:::...:....:...|:...:.|||..:|...|.|..::::.:.::::....||||||..
Yeast   336 ASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYR 400

  Fly   381 PSGPLTARKATANCTIN-DFFIPKGSDVIISPIYMG-RCKDFFPDPMVFKPDRWAIGAEPKIEAT 443
            |...:.......|..:: ::..|||: ::|..:|.. ...:.:.:|..|.|:||..|::......
Yeast   401 PPVLMVPYVVKKNFPVSPNYTAPKGA-MLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKK 464

  Fly   444 TFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLF--------EPLGERQVKLKLNFVITLHTVE 500
            .::.|..|...|:||.|.|:    ..|.||..|..        .||.|     |:....|:...:
Yeast   465 NWLVFGCGPHVCLGQTYVMI----TFAALLGKFALYTDFHHTVTPLSE-----KIKVFATIFPKD 520

  Fly   501 PYLCRAKNLD 510
            ..|...|..|
Yeast   521 DLLLTFKKRD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	103/522 (20%)
ERG5	NP_013728.1	CYP61_CYP710	103..522	CDD:410703	95/474 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I1557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I1313
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53736
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	5	4.970