Protein Alignment Cyp312a1 and Cyp4x1

DIOPT Version :10

• Sequence 1: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001003947.1
• Gene: Cyp4x1 / 81906
• MGIID: 1932403
• Length: 507
• Species: Mus musculus
• Alignment Length: 497
• Identity: 139/497 - (27%)
• Similarity: 230/497 - (46%)
• Gaps: 68/497 - (13%)

  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGH--------LHILAKLVGPHPLRRATEM 64
            :|:.|:.|||     |:.|:.|....:|.|||...:||        :..|.::|..||.
Mouse    25 VLMQAMKLYL-----RRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKKHPC------ 78

  Fly    65 INEHLHDHRAKLWMG-------------TKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLC 116
                    ....|:|             .|::|...:|| :|.|   .|||...         :.
Mouse    79 --------AFPCWVGPFQAFFYIYDPDYAKIFLSRTDPK-MQYL---HQLLTPC---------IG 122

  Fly   117 EGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAK-FAESGDQIDFLQLISCF 180
            .||......:|...|.::.|||:..::|..|.......:::|....| :......|:..:.|:..
Mouse   123 RGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLM 187

  Fly   181 TLDTICETALGVSVGSQSSAKSE-YLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIK 244
            |||.|.:.|.|.....|.:...| |:.|...:..||..||.|.::.:..|||.:......|||.|
Mouse   188 TLDIIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGK 252

  Fly   245 TLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREE 309
            .:|.:||.|||.|          :....:..:.|..:.:..|||.:|.::..|.:..:..|:|.|
Mouse   253 VIHQYTEKIIQDR----------KKILKNQVKQDDTQTSQIFLDIVLSAQAEDERAFSDADLRAE 307

  Fly   310 VDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIK 374
            |:|.::.|.|.:|.::::.:|.:.|:||||.|||.|:.|:.|...|  |:.||:.::.:...|||
Mouse   308 VNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSS--ITWEQLDEMSYTTMCIK 370

  Fly   375 ETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEP 438
            ||||:.|..|..:|:.:...|:.| ..:|.|..|::|...:......:.||.||.|.|:......
Mouse   371 ETLRLIPPVPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSD 435

  Fly   439 KIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            :.....|:||.:|.|:|:||::||:.||:.:|.:|.:|...|
Mouse   436 QRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQVAP 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	121/422 (29%)
Cyp4x1	NP_001003947.1	CYP4B-like	66..500	CDD:410771	125/451 (28%)