DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	497	Identity:	139/497 - (27%)
Similarity:	230/497 - (46%)	Gaps:	68/497 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGH--------LHILAKLVGPHPLRRATEM 64
            :|:.|:.|||     |:.|:.|....:|.|||...:||        :..|.::|..||.
Mouse    25 VLMQAMKLYL-----RRQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKKHPC------ 78

  Fly    65 INEHLHDHRAKLWMG-------------TKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLC 116
                    ....|:|             .|::|...:|| :|.|   .|||...         :.
Mouse    79 --------AFPCWVGPFQAFFYIYDPDYAKIFLSRTDPK-MQYL---HQLLTPC---------IG 122

  Fly   117 EGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAK-FAESGDQIDFLQLISCF 180
            .||......:|...|.::.|||:..::|..|.......:::|....| :......|:..:.|:..
Mouse   123 RGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLM 187

  Fly   181 TLDTICETALGVSVGSQSSAKSE-YLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIK 244
            |||.|.:.|.|.....|.:...| |:.|...:..||..||.|.::.:..|||.:......|||.|
Mouse   188 TLDIIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGK 252

  Fly   245 TLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREE 309
            .:|.:||.|||.|          :....:..:.|..:.:..|||.:|.::..|.:..:..|:|.|
Mouse   253 VIHQYTEKIIQDR----------KKILKNQVKQDDTQTSQIFLDIVLSAQAEDERAFSDADLRAE 307

  Fly   310 VDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIK 374
            |:|.::.|.|.:|.::::.:|.:.|:||||.|||.|:.|:.|...|  |:.||:.::.:...|||
Mouse   308 VNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSS--ITWEQLDEMSYTTMCIK 370

  Fly   375 ETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEP 438
            ||||:.|..|..:|:.:...|:.| ..:|.|..|::|...:......:.||.||.|.|:......
Mouse   371 ETLRLIPPVPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSD 435

  Fly   439 KIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            :.....|:||.:|.|:|:||::||:.||:.:|.:|.:|...|
Mouse   436 QRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQVAP 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	131/470 (28%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	131/470 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840