Protein Alignment Cyp312a1 and cyp17a2

DIOPT Version :10

• Sequence 1: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001099140.1
• Gene: cyp17a2 / 796487
• ZFINID: ZDB-GENE-100822-1
• Length: 495
• Species: Danio rerio
• Alignment Length: 548
• Identity: 126/548 - (22%)
• Similarity: 218/548 - (39%)
• Gaps: 116/548 - (21%)

  Fly     6 FGLLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLH 70
            |..|||   |.||.|......:...:..:|..|.||.:|.|..|...:.||.|  .|::.::  :
Zfish    10 FSALLL---LLLLLVRRLLEGVGSSSVSFPCLPRLPLLGSLLHLRSNLPPHLL--FTQLSSQ--Y 67

  Fly    71 DHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEK--------- 126
            .....|:.|..|.||   ..:|..:  .:.|||:..::......:...|.|.|.:.
Zfish    68 GPLFGLYAGPHLTLV---VSEIGLV--REVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPL 127

  Fly   127 WSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALG 191
            |.:.|::|..:|..                       |.|..::   ||.|.....|::||..
Zfish   128 WKNHRRLVHSSFTL-----------------------FGEGSNK---LQTIVQEAADSLCEEL-- 164

  Fly   192 VSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQ- 255
            .:...|||          .:.|::.:.:.|:..|..|    :|.|:.....::|:..:.:||:|
Zfish   165 QACRGQSS----------DLSVVLMRAVTNVICRLVF----SSSYQPSDPELQTVIQYNDGIVQT 215

  Fly   256 ---------------------KRIDEI----NQDAENRNYQSSDAELDGVKRTLCFLDTLLL--S 293
                                 ||:.|.    :|....:..:...:...|..|.|  ||.||:  .
Zfish   216 IARGGLVDIFPWLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDL--LDALLIGQQ 278

  Fly   294 KGPDGKPLTVKDIREEVDTII------FG-GFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCG 351
            :|..|    ..||.|  |.::      || |.:.|:|||.:.:..:..||:.|:|.:.|:....|
Zfish   279 RGSGG----ADDITE--DHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVG 337

  Fly   352 KDKSEPISIEQVRQLEFLEACIKETLRMYPSGP-LTARKATANCTINDFFIPKGSDVIISPIYMG 415
            .|:  |..:.....|..|:|.:.|.:|:.|..| |....|..:.::....:|||:.|:::...:.
Zfish   338 VDR--PPCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIH 400

  Fly   416 RCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            .....:..|..|.|:|:...:..|...::|:||.||.|.|:|:..|.:.|.:.::..|:.|.|..
Zfish   401 HDPKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSC 465

  Fly   481 LGERQV-KLKLNFVITLH------TVEP 501
            ..|..: .|:..|.:.|.      ||.|
Zfish   466 PSEASLPDLQGRFGVVLQPERYTVTVTP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	107/479 (22%)
cyp17a2	NP_001099140.1	CYP17A1	67..489	CDD:410766	104/478 (22%)