DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	519	Identity:	162/519 - (31%)
Similarity:	260/519 - (50%)	Gaps:	46/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLALSLYLL-------YVF-ERQSRIDRLTHKWPAPPALP-FIGHLHILAKLVGPHPLRRATE 63
            ||||.::.::|       |.| |..||:.    .:|.||... |.|||.::..  ....::..||
Mouse    21 LLLLGVASWILARILAWTYSFYENCSRLS----CFPQPPKKNWFSGHLGMIQS--NEEGMQLVTE 79

  Fly    64 M----INEHLHDHRAKLWMG---TKLYLVDCNPKDIQALCSAQQLL--QKTNDYRVFENWLCEGL 119
            |    .:.||      .|:|   ..|.:||  |..:..|..|..|:  :.....|..:.||.:||
Mouse    80 MGQTFQDVHL------FWLGPVIPVLRIVD--PAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGL 136

  Fly   120 FTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGD-QIDFLQLISCFTLD 183
            |.|..:|||..|:::.|||::.::|.:|.:|.:...|:.......:..|. :::..:.||..|||
Mouse   137 FLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLD 201

  Fly   184 TICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHG 248
            ::.:...|.....|.| .|||:.|:..:..:|.||...:|....|::..|:..:|.::....:|.
Mouse   202 SLQKCLFGFDSNCQES-PSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHN 265

  Fly   249 FTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTI 313
            ||:.:|::|...::....:...:|...     .:||.|:|.|||:|...||.|:.:|||.|.||.
Mouse   266 FTDAVIRERRHTLSSQNHDEFLKSKTK-----SKTLDFIDVLLLAKDEHGKELSDEDIRAEADTF 325

  Fly   314 IFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLR 378
            :|||.|.||:.|::.:||:..|||:|:|||:||..:....:.|.|..:.:.||.||..||||:||
Mouse   326 MFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQLPFLTMCIKESLR 390

  Fly   379 MYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEA 442
            ::.......|:.|.:..:.| ..||||:..:||...:......:|||.|:.|.|:......|...
Mouse   391 LHSPVIDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENPQKRSP 455

  Fly   443 TTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLF-----EPLGERQVKLKLNFVITLHTVEP 501
            ..||||.||.|:|:||.:||..:|:.||..|..|..     ||..:.::.|:....:.|. |||
Mouse   456 LAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLR-VEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	152/484 (31%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	148/477 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750