DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	161/501 - (32%)
Similarity:	251/501 - (50%)	Gaps:	53/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGFGLLLLALSLYLLYVF-ERQSRIDRLTHKWPAPPALP-FIGHLHILAKLVGPHPLRRATEM-- 64
            ||....:||..|...|.| |..||:    ..:|..|... |:|||.::..  ....::..|||
  Rat    24 LGAASWILARILAWTYSFCENCSRL----RCFPQSPKRNWFLGHLGVIQS--NEEGMQLVTEMGQ 82

  Fly    65 --INEHLHDHRAKLWMG---TKLYLVDCNPKDIQALCSAQQLLQKTND--YRVFENWLCEGLFTS 122
              .:.||      :|:|   ..|.|||  |..:..|..|..|:...:.  ....:.||.:|||.|
  Rat    83 TFRDVHL------IWLGPVSPVLRLVD--PAFVAPLLQAPALVAPKDPTFLHFLKPWLGDGLFLS 139

  Fly   123 GFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKF----AESGDQIDFLQLISCFTLD 183
            ..:|||..|:::.|||::.::|.:|..|.:...|:   .||:    .|...:::..:.||..|||
  Rat   140 SGDKWSRHRRLLTPAFHFDILKPYVKTFNQSVNIM---HAKWKHLCLEGSARLEMFENISLMTLD 201

  Fly   184 TICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHG 248
            ::.:...|.....|.| .|||:.|...:..:..||...:|....|::.||:..:|.::....:|.
  Rat   202 SLQKCLFGFDSNCQES-PSEYISATLELSSLTRKRSYKLFLYLDFLYYRTADGQRFRKACDLVHS 265

  Fly   249 FTEGIIQKR--------IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKD 305
            ||:.:|::|        :||.   .|::....|        :||.|:|.|||:|...||.|:.:|
  Rat   266 FTDAVIRERRRLLSSQGVDEF---LESKTKSKS--------KTLDFIDVLLLAKDEHGKELSDED 319

  Fly   306 IREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLE 370
            ||.|.||.:|||.|.||:.|::.:||:..|||:|:|||:|||.:....:.|.|..:.:.||.||.
  Rat   320 IRAEADTFMFGGHDTTASALSWILYNLASHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLT 384

  Fly   371 ACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAI 434
            .||||:||::|......|:.|.:..:.| ..||||:..:||...:......:|||.|:.|.|:..
  Rat   385 MCIKESLRLHPPAVDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDP 449

  Fly   435 GAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            ....|....:||||.||.|:|:||.:||..:|:.:...|..|.|.|
  Rat   450 ENRQKRSPLSFIPFSAGPRNCIGQTFAMNEVKVAVGLTLLRFRFLP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	151/469 (32%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	145/445 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850