DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	519	Identity:	159/519 - (30%)
Similarity:	261/519 - (50%)	Gaps:	38/519 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGFGLLLLALSLYLL-------YVF-ERQSRIDRLTHKWPAPPALP-FIGHLHILAKLVGPHPLR 59
            |.:.||||..:.::|       |.| |..||:    ..:|.||... |:|||.::..  ....::
Mouse    17 LSWHLLLLGAASWILARILAWTYSFCENCSRL----RCFPQPPKRNWFLGHLGMIEH--NEEGMQ 75

  Fly    60 RATEMINEHLHDHRAKLWMG---TKLYLVDCNPKDIQALCSAQQLL-QKTNDYRVF-ENWLCEGL 119
            ..||....:...|..  |:|   ..|.:||  |..:..|..|..|: .|...:..| :.||.:||
Mouse    76 LMTEAGQTYRDVHLC--WLGPVIPVLRIVD--PAFVAPLLLASALVAPKDTTFHTFVKPWLGDGL 136

  Fly   120 FTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGD-QIDFLQLISCFTLD 183
            |.:..:|||..|:::.|||::.::|.:|.:|.:...|:.......:..|. :::..:.||..|||
Mouse   137 FLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLD 201

  Fly   184 TICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHG 248
            ::.:...|.....|.| .|||:.|:..:..::.||...:|....|::..|:..:|.::....:|.
Mouse   202 SLQKCLFGFDSNCQES-PSEYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKACDLVHN 265

  Fly   249 FTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTI 313
            ||:.:|::|...::....:...:|...     .:||.|:|.|||:|...||.|:.:|||.|.||.
Mouse   266 FTDAVIRERRHTLSSQNHDEFLKSKTK-----SKTLDFIDVLLLAKDEHGKELSDEDIRAEADTF 325

  Fly   314 IFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLR 378
            :|||.|.||:.|::.:||:..|||:|:|||:||..:....:.:.|..:.:.||.||..||||:||
Mouse   326 MFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDDLAQLPFLTMCIKESLR 390

  Fly   379 MYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEA 442
            ::|......|:.|.:..:.| ..||||:..:||...:......:|||.|:.|.|:......|...
Mouse   391 LHPPVIDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENAHKRPP 455

  Fly   443 TTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLF-----EPLGERQVKLKLNFVITLHTVEP 501
            ..||||.||.|:|:||.:||..:.:.||..|..|..     ||..:.::.|:....:.|. |||
Mouse   456 LAFIPFSAGPRNCIGQTFAMNEMMVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLR-VEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	148/480 (31%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	137/450 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750