DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	539	Identity:	172/539 - (31%)
Similarity:	275/539 - (51%)	Gaps:	68/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLGFG--------LLLLALSLYLL-------YVFERQSRIDRLTHKWPAPPALP-FIGHLHILAK 51
            |||..        ||||.:..:||       |.|....|  || ..:|.||... |.|||.::..
Human     8 WLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCR--RL-QCFPQPPKRNWFWGHLGLITP 69

  Fly    52 LVGPHPLRRATEMINEHLHDHRAKLWMGTKL-YLVDCNPKDIQALCSAQ-QLLQKTNDY-RVFEN 113
            .  ...|:.:|:|  ...:.....:|:|..: ::|.|:|..|:::.:|. .:..|.|.: |..:.
Human    70 T--EEGLKNSTQM--SATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKP 130

  Fly   114 WLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESG-DQIDFLQLI 177
            ||.||:..||.:|||..|:::.|||::.::|.::.:|.|.:.|:|......|..| .::|..:.|
Human   131 WLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHI 195

  Fly   178 SCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQEL 242
            |..|||::.:.........| ...|||:..:..:..:::||.::|.....|::..:...:|....
Human   196 SLMTLDSLQKCIFSFDSHCQ-ERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRA 259

  Fly   243 IKTLHGFTEGIIQKR--------IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGK 299
            .:.:|.||:.:|::|        ||:..:|...             .:||.|:|.|||||..|||
Human   260 CRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAK-------------SKTLDFIDVLLLSKDEDGK 311

  Fly   300 PLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIE--Q 362
            .|:.:|||.|.||.:|||.|.||:.|::.:||:..|||:|:|||:||..:. ||: :|..||  .
Human   312 ALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELL-KDR-DPKEIEWDD 374

  Fly   363 VRQLEFLEACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMV 426
            :.||.||..|:||:||::|..|..:|..|.:..:.| ..||||...:|..|.:......:|||.|
Human   375 LAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEV 439

  Fly   427 FKPDRW----AIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVK 487
            :.|.|:    :.|..|    ..||||.||.|:|:||.:||..:|:|||.:|.:|.|.| ...:.:
Human   440 YDPFRFDPENSKGRSP----LAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP-DHTEPR 499

  Fly   488 LKLNFVITLH-----TVEP 501
            .||..::...     .|||
Human   500 RKLELIMRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	158/492 (32%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	155/478 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750