DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	516	Identity:	169/516 - (32%)
Similarity:	258/516 - (50%)	Gaps:	68/516 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLGFG--------LLLLALSLYLL-------YVFERQSRIDRLTHKWPAPPALP-FIGHLHILAK 51
            |||.|        ||||....:||       |.|....|  || ..:|.||... |.||    ..
Human     8 WLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCR--RL-QCFPQPPKQNWFWGH----QG 65

  Fly    52 LVGP--HPLRRATEMINEHLHDHRAKLWMG-TKLYLVDCNPKDIQALCSAQQLLQKTN--DYRVF 111
            ||.|  ..::..|:::.  .:....|||:| |...|:.|:|..|:.:.||...:...:  .|...
Human    66 LVTPTEEGMKTLTQLVT--TYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFL 128

  Fly   112 ENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGD-QIDFLQ 175
            :.||.:||..||.:|||..|:::.|||::.::|.::.:|.|...|:.....:.|..|. ::|..:
Human   129 KPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFE 193

  Fly   176 LISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQ 240
            .||..|||::.:.........|.. .|||:.|:..:...::||.:.|.....|::..|...:|.:
Human   194 HISLMTLDSLQKCVFSFESNCQEK-PSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFR 257

  Fly   241 ELIKTLHGFTEGIIQKR--------IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPD 297
            .....:|.||:.:||:|        ||:..::...             .:||.|:|.|||||..|
Human   258 RACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAK-------------SKTLDFIDVLLLSKDED 309

  Fly   298 GKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIE- 361
            ||.|:.:|||.|.||.:|.|.|.||:.|::.:|::..|||:|::||:||..:. ||: |||.||
Human   310 GKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELL-KDR-EPIEIEW 372

  Fly   362 -QVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDF------FIPKGSDVIISPIYMGRCKD 419
             .:.||.||..||||:||::|..|:.:|     |...||      .||||...:|:.|.:.....
Human   373 DDLAQLPFLTMCIKESLRLHPPVPVISR-----CCTQDFVLPDGRVIPKGIVCLINIIGIHYNPT 432

  Fly   420 FFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            .:|||.|:.|.|:......:.....||||.||.|:|:||.:||..:|:|||..|.:|...|
Human   433 VWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	154/469 (33%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	154/469 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750