DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	493	Identity:	167/493 - (33%)
Similarity:	266/493 - (53%)	Gaps:	50/493 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HKW----PAP---PALPFIGHL-------HILAKLVGPHPLRRATEMINEHLHDHRAKLWMGTKL 82
            |||    |.|   ...||||:.       ....:|||     ..||..|..|    .|:|:|...
Zfish    35 HKWKELKPIPGIGNTFPFIGNALQFKSNGDFFLQLVG-----YTTEFQNSPL----LKIWIGPIP 90

  Fly    83 YLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFV 147
            :|:..:.:.::.:.:....:.|...|:....||..||.||..:||..|||::.|.|:::::.:|:
Zfish    91 FLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRKMLTPTFHFSILTEFL 155

  Fly   148 AVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSIL 212
            .|..:|:.:|:..:.|.|..|....|..:..| .||.|||||:|..:.:||:..|||:..|..:.
Zfish   156 EVMNEQAEVLIEKLEKQAGKGPFNCFSHITLC-ALDIICETAMGKRIYAQSNYDSEYVRTVYRMS 219

  Fly   213 VIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAEL 277
            .||.:|.:..:|...|::......:.....:|.||.|||.:       ||:.||..:|..||:|.
Zfish   220 DIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTESV-------INERAEYLSYVESDSES 277

  Fly   278 D-GVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQR 341
            | |:::...|||.||.:|..|||.||.|||:|||||.:|.|.|.||..:|:.::.:..|||.|::
Zfish   278 DQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRK 342

  Fly   342 CREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSD 406
            .::|::.|.| :...|::.|.:::|.:||..|||:||::||.|..||....:..||.|.:|||::
Zfish   343 AQQELFEVFG-ESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQINGFKVPKGTN 406

  Fly   407 VIISPIYMGRCKDFFPDPMVFKPDRW----AIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKM 467
            :::....:.|...|||||..|:|:|:    .:|..|    ..:|||.||.|:|:|||:|::..|:
Zfish   407 IVVITYALHRDPRFFPDPEEFRPERFLPENCVGRHP----YAYIPFSAGLRNCIGQRFAIMEEKV 467

  Fly   468 VLAHLLRNF---------LFEPLGERQVKLKLNFVITL 496
            :||::||.|         ...||||..::.:....|||
Zfish   468 ILAYILRYFNIVACQKREELRPLGELVLRPEQGIWITL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	164/486 (34%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	160/478 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840