DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	550	Identity:	123/550 - (22%)
Similarity:	225/550 - (40%)	Gaps:	129/550 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLALSLYLLYVFERQSRIDRLTHKW----------PAPPALPFIGHLHILAKLVGPHPLRRATE 63
            :|:.|.|.|||::          ..|          |.|...||.|......|......:    |
Zfish    12 ILVVLVLTLLYMY----------GVWPHGFFKKLGIPGPRPWPFFGTFLSYTKGFFNFDM----E 62

  Fly    64 MINEH-----LHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENW--------- 114
            ...::     ::|.|..:.|.|.|.::              :.:.....|..|.|.
Zfish    63 CAKKYGKVWGIYDGRLPILMVTDLEMI--------------KTIMVKECYSTFTNRREINVDLAG 113

  Fly   115 -LCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKF---AESGDQ---ID 172
             |.:|:.....|:|...|..:.|.|....:|:   :|.    |.:|:..:|   .:.||.   :.
Zfish   114 PLADGITAVKDERWKRIRGTLSPYFTSGRLKE---IFP----IAMTHADRFIKNMQKGDHEQPVK 171

  Fly   173 FLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVK-------------------SILVIIDKR 218
            ..::::.::||.:..:|..|.:.|.::....::..:|                   ||..::.|.
Zfish   172 IKEVMASYSLDVVTSSAFSVDIDSINNPDDPFVTNIKNFLKFNLFGLFVLLLTVFPSIANLLGKM 236

  Fly   219 LKNIFYRNS--FIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVK 281
            ..::|.:.:  |.:|.....|.|.:.......|...:||..|.:                 |.||
Zfish   237 GLSMFSKPTVDFFYKALRKIKEEHKDSNGRVDFFRLMIQNEIPD-----------------DQVK 284

  Fly   282 RTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEV 346
            .|        .|:.|: |.||..:|..:....|.||::.|:|||.|.:||:.::|:..::..|::
Zfish   285 DT--------TSEQPE-KGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKI 340

  Fly   347 WSVCGKDKS----EPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDV 407
                  ||:    .|||.:.:.::::||..|.|::|:.|:.|...|.......:|...|||.:.:
Zfish   341 ------DKNFPLDTPISYDALMKIDYLEMSINESMRLLPTAPRLERVCKKTVEMNGITIPKDTMI 399

  Fly   408 IISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHL 472
            .|....:.:....:..|..|:|:|::...:.:.....|:||..|.|:|:|.|||::::|:::..|
Zfish   400 TIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRYALMIVKLLVVKL 464

  Fly   473 LRNFLFEPLGERQVKLKLNFV------ITL 496
            |:||..|...|.|:.|:||.|      |||
Zfish   465 LQNFSVETCKETQIPLELNPVFQPKVPITL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	115/513 (22%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	115/513 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010