DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	165/558 - (29%)
Similarity:	266/558 - (47%)	Gaps:	89/558 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLGFG------LLLLAL------------SLYLLYVFERQSRIDRLTHKWPAPPALP-FIGHLHI 48
            |||.|      .|||:|            .:|.||     ::..||. .:|.||... |.|||
  Rat     8 WLGLGPMSASPWLLLSLVGVSWFLTRCLTQIYTLY-----AKCQRLC-GFPQPPKRSWFWGHL-- 64

  Fly    49 LAKLVGPHP-----LRRATEMINEHLHDHRAKLWMGTKLYLVD-CNPKDIQALCSAQQLLQKTND 107
                 |..|     :::.||::..:......  |:|..:.|:. |:|..|:::.||...:...:.
  Rat    65 -----GMSPPTEEGMKQMTELVATYPQGFMT--WLGPIVPLITLCHPDIIRSVLSASAAVAPKDG 122

  Fly   108 --YRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGD- 169
              |...:.||.:||..|..:|||..|.::.|||::.::|.:|.:|...:.|:.....:.|..|.
  Rat   123 IFYSFLKPWLGDGLLVSASDKWSRHRSMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSA 187

  Fly   170 QIDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTS 234
            .:|..:.||..||||:.:.....:...|.. .|||:.|:..:..::.||.:.:......:::.|.
  Rat   188 HLDMFENISLMTLDTLQKCVFSFNSNCQEK-PSEYIAAILELSALVVKRNEQLLLHMDLLYRLTP 251

  Fly   235 HYKREQELIKTLHGFTEGIIQKR---------IDEINQDAENRNYQSSDAELDGVKRTLCFLDTL 290
            ..:|..:....:|.||..:||:|         .|.|...|::              :||.|:|.|
  Rat   252 DGRRFYKACHLVHDFTYAVIQERRRTLPKHGGDDVIKAKAKS--------------KTLDFIDVL 302

  Fly   291 LLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKS 355
            ||||..|||.|:.:|||.|.||.:|.|.|.||:.|::.:||:..|||:|:|||:||..:.....|
  Rat   303 LLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDS 367

  Fly   356 EPISI-------EQVRQLEFLEACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPI 412
            |.|..       :.:.||.||..||||:||::|...:.:|..|.:.::.| ..||||...||:..
  Rat   368 EEIECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRVIPKGIICIINIF 432

  Fly   413 YMGRCKDFFPDPMVFKPDRWAIGAEPK-IEATT---FIPFMAGARSCMGQRYAMVMLKMVLAHLL 473
            ........:.||.|:.|.|:    :|: |:|.:   ||||.||.|:|:||.:||..:|:.:|..|
  Rat   433 ATHHNPTVWQDPEVYDPFRF----DPENIQARSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTL 493

  Fly   474 RNFLFEPLGERQVKLKLNFVITLH-----TVEPYLCRA 506
            ..|...| .:::.:.|...::...     .|||...:|
  Rat   494 LRFRVLP-DDKEPRRKPELILRAEDGLWLRVEPLSAQA 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	151/505 (30%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	139/469 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750