DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp312a1 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	165/506 - (32%)
Similarity:	284/506 - (56%)	Gaps:	29/506 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLALSLYLLY---------VFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEM 64
            :||.|.:.||:         ..:|:.::..|    |.|...|.||.:.::.:|.....::...|.
  Fly     1 MLLFLLVVLLFGAGWIIHLGQADRRRKVANL----PGPICPPLIGAMQLMLRLNPKTFIKVGREY 61

  Fly    65 INEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSH 129
            :.:  ..|..::|:..:|.::..:.:..:.|.|:|:.|.|...|:|...||..||..|..:.|..
  Fly    62 VLK--FGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQ 124

  Fly   130 RRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGVSV 194
            ||||:.|.|::::::|||.||::||.|.:..:|:.| :|:..|..:.|....||.|.|||:|..:
  Fly   125 RRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKA-NGNTFDVYRSICAAALDIIAETAMGTKI 188

  Fly   195 GSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRT-SHYK-REQELIKTLHGFTEGIIQKR 257
            .:|::..:.|.:||.....::..|..:::.:...:|..| .|.| |:.:||:|:..||..:|:||
  Fly   189 YAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKR 253

  Fly   258 IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTA 322
            ...: :|.:::...::|.:: |.||.:..||.||:|. .||:|||..:|||||||.:|.|.|.|.
  Fly   254 RQAL-EDQQSKLMDTADEDV-GSKRRMALLDVLLMST-VDGRPLTNDEIREEVDTFMFEGHDTTT 315

  Fly   323 TTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTA 387
            :.|:|.::.::.|||.|.:..||:..|.|.|:|.|:||..:.:|:::|..|||:|||||..|:..
  Fly   316 SALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVG 380

  Fly   388 RKAT-----ANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIP 447
            ||..     .:....|..||.||::||....:.|..:.||:|..|.|:|...|:  ::.....||
  Fly   381 RKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGS--RVAPFKMIP 443

  Fly   448 FMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVITLHT 498
            |.||.|:|:||::|.:.:||:||.::|.:...|:|:| |:..:|.|:...|
  Fly   444 FSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQR-VECIVNIVLRSET 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	158/471 (34%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	151/435 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449056
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.990