DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	501	Identity:	137/501 - (27%)
Similarity:	233/501 - (46%)	Gaps:	72/501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FGLLLLA--LSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEH 68
            |.|:.||  |::..|.:..|:.  .:...::|.|||....||:....:  ..|.|.:..:.:  .
Zfish    17 FALIFLACLLTVVKLLIVRRKG--VKTMERFPGPPAHWLFGHVKEFRQ--DGHDLEKIVKWM--E 75

  Fly    69 LHDHRAKLWMG-------------TKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLF 120
            |:.....||.|             .|..|....|||..|             |:.|..||.:||.
Zfish    76 LYQFAFPLWFGPSLAVLNIHHPSYVKTILTTTEPKDDYA-------------YKFFIPWLGDGLL 127

  Fly   121 TSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTI 185
            .|..:||...|:::.|.|:|.::|.:|.:....::::|......:.|.:..:..:.:|..|||:|
Zfish   128 VSTGQKWFRHRRLLTPGFHYDVLKPYVKLISDSTKVMLDKWEVHSRSEESFELFKHVSLMTLDSI 192

  Fly   186 CETALGVSVGSQS-SAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGF 249
            .:.|...:...|: |..:.|:.||..:..:::.|.:...|.:..||..:.|..|.::.....|..
Zfish   193 MKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNH 257

  Fly   250 TEGIIQKRIDEINQDAE-----NRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREE 309
            |..:|:||.:.:..:.|     ||.|             |.|||.||.::....:.|:.:|||.|
Zfish   258 TAEVIRKRKEVLKMEEEQGIVKNRRY-------------LDFLDILLSARDEHQQGLSDEDIRAE 309

  Fly   310 VDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIK 374
            |||.:|.|.|.||:.:::..||:..:||||::||:|:....  |....:..|.:.::.:...|||
Zfish   310 VDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQAL--DGKATLEWEDLNKIPYTTMCIK 372

  Fly   375 ETLRMYPSGPLTARKATANCTINDFF----IPKGSDVIIS--PIYMGRC---KDFFPDPMVFKPD 430
            |:||::|..|..:||.|...|   ||    :|:|..:.:|  .|:|...   ..:..||:.|.|:
Zfish   373 ESLRLHPPVPGISRKLTKPLT---FFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPE 434

  Fly   431 RWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNF 476
            ..| ...|.    .|:||.||.|:|:||.:||..:|:.:|..|:.:
Zfish   435 NVA-NRSPH----AFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRY 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	130/470 (28%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	130/470 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750