DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp312a1 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	146/523 - (27%)
Similarity:	266/523 - (50%)	Gaps:	58/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGFGLLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMIN-- 66
            ||..:||..|:|.|.:: .:...|..||.:.......|....:.|:.   |........:::|
  Fly     6 LGIPILLAVLTLLLKHI-NKTYFILSLTKRVRTEDGSPLESKVAIMP---GKTRFGNNLDILNFT 66

  Fly    67 -----EHLHDHRAK------LW--MGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEG 118
                 ..:.:..||      ||  :...:|.| ..|::.:.:..:.:|:.|...|.:...:|.:|
  Fly    67 PASVFNFVRESTAKAKGQNYLWYFLYAPMYNV-VRPEEAEEVFQSTKLITKNVVYELIRPFLGDG 130

  Fly   119 LFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLD 183
            |..|...||..|||.:.|||::.:::.|:.:|:::.:..|..:.|..::  :::..|:|..|||:
  Fly   131 LLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDA--ELELNQVIPPFTLN 193

  Fly   184 TICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKN-IFYRNSFIFKRTSHYKREQELIKTLH 247
            .||||||||.:...|.. :||..|:.:|..::.:|:.| :.|.|.:.|. ...|::..:.::.:|
  Fly   194 NICETALGVKLDDMSEG-NEYRKAIHAIEEVLIQRVCNPLMYYNWYFFV-YGDYRKHLQNLRIVH 256

  Fly   248 GFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDT 312
            .|:..||:::..:..|.      |..:.:..|.|:....|||||.::. ||: :..:.|.:||:|
  Fly   257 DFSSRIIERKRQQFQQK------QLGEVDEFGRKQRYAMLDTLLAAEA-DGQ-IDHQGICDEVNT 313

  Fly   313 IIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETL 377
            .:|.|:|.|:|.|.|.:..:.||.:.|::|.|||.::  .:.|:.||:.|..:|.:||..|||:|
  Fly   314 FMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENL--PEDSDDISMFQFNKLVYLECVIKESL 376

  Fly   378 RMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRW----AIGAEP 438
            ||:||.|...|:......:|...:||.:.:.|....:.|....||.|.:|:|||:    .:...|
  Fly   377 RMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPENTVNRHP 441

  Fly   439 KIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPL---------------GERQVKL 488
                ..::||.||.|:|:||::|::.:|::||.::|||...|.               .:..:|:
  Fly   442 ----FAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQENIKV 502

  Fly   489 KLN 491
            ||:
  Fly   503 KLS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	136/492 (28%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	128/436 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460542
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.990