DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	169/492 - (34%)
Similarity:	261/492 - (53%)	Gaps:	42/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALSLYLLY-VFERQ-------SRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMIN- 66
            |||..::|: .|.|.       .|:.|.....|.|.    ||.|  :|.:       :..|::|
  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPT----IGEL--IANV-------KKGEILNW 55

  Fly    67 ----EHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKW 127
                ...|....::|.|..|.::..:|:||:.|....|||.|:.:|.:.|.||.:||.|:|.|.|
  Fly    56 LKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESW 120

  Fly   128 SHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGV 192
            ..|||::.|.|::.::.:|....|:..|||:..:...| :|:..|....|:.|.||.|||||:|:
  Fly   121 HRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICETAMGI 184

  Fly   193 SVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKR 257
            ...:|..:.|||:.||:||..::.|:..:.:.|.:..||.|...|..:..:|.||..|..:|:.|
  Fly   185 KKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLR 249

  Fly   258 IDEINQDAENRNYQSSDAELD--GVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDL 320
            .:::.|:   ||....:||.|  |.||.|.|||.|||::...|..|:..||||||||.:|.|.|.
  Fly   250 REQLIQE---RNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDT 311

  Fly   321 TATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPL 385
            |::.:.|.:..::.:|:.|||..||...:.|::|         ..:.:|||.||||||:|||.|.
  Fly   312 TSSAIAFALSLLSKNPDVQQRAFEEASELEGREK---------ESMPYLEAVIKETLRIYPSVPF 367

  Fly   386 TARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMA 450
            .:||...:..:....:|||:.:......:.|....||||..|.|||:.:. |.::....|..|.|
  Fly   368 FSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVN-EKQMHPFAFAAFSA 431

  Fly   451 GARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVK 487
            |.|:|:||::||:.||..||.|||::.|.|..:.|.|
  Fly   432 GPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	161/460 (35%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	161/461 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460460
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	8.890