DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp312a1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	148/526 - (28%)
Similarity:	260/526 - (49%)	Gaps:	44/526 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFWLGFGLLLLALSLYLLYVFERQSRIDRLTHK----WPAPPALPF-IGHLHILAKLVGPHPLRR 60
            :.:|.|.|||.|..|:..:         |:|.:    :|.||...: :||:.:.  |.....|:.
  Rat    31 LLFLLFRLLLQAFKLFSDF---------RITCRRLSCFPEPPGRHWLLGHMSMY--LPNEKGLQN 84

  Fly    61 ATEMINEHLHDHRAKLWMGTKL-YLVDCNPKDIQALCSAQQLLQKTND--YRVFENWLCEGLFTS 122
            ..::: :.:| |....|:|..| .||..:|..|:.:..|...:...::  |...:.||.:||..|
  Rat    85 EKKVL-DTMH-HIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLIS 147

  Fly   123 GFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGD--QIDFLQLISCFTLDTI 185
            ...|||..|:::.|||::.::|.::.:|.:...|:.....:....|.  ..|..:.:|..|||::
  Rat   148 KGNKWSRHRRLLTPAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSL 212

  Fly   186 CETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFT 250
            .:.....|...|... |:|:.::..:..::.:|...:.:...||:..|:..:|.::...|:|.||
  Rat   213 QKCVFSYSSDCQEKL-SDYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQACDTVHNFT 276

  Fly   251 EGIIQKR---IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDT 312
            ..:||:|   :.|:..:|..:..|.         :||.|:|.|||:|..:||.|:.:|||.|.||
  Rat   277 TEVIQQRRRALRELGAEAWLKAKQG---------KTLDFIDVLLLAKDEEGKELSDEDIRAEADT 332

  Fly   313 IIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETL 377
            .:|.|.|.|::.|::.::|:..:||:|.:||||:..|....:.|.:..:.:.||.|...||||:|
  Rat   333 FMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKESL 397

  Fly   378 RMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDF-FPDPMVFKPDRWAIGAEPKI 440
            |.:|...|.:|:.|.:..:.| ..||||...::| ||....... :||..|:.|.|:......:.
  Rat   398 RQFPPVTLISRRCTEDIKLPDGRIIPKGIICLVS-IYGTHYNPLVWPDSKVYNPYRFDPDIPQQR 461

  Fly   441 EATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVITLH-----TVE 500
            ....|:||.||.|:|:||.:||..:::|:|..|..|.......|:|:.|...::...     .||
  Rat   462 SPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLNVE 526

  Fly   501 PYLCRA 506
            |...||
  Rat   527 PLPSRA 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	137/485 (28%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	128/453 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750