DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	143/505 - (28%)
Similarity:	241/505 - (47%)	Gaps:	67/505 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GF--GLLLLALSLYLL----YVFERQSRIDRLTHKWPAPPALPFIGH----------LHILAKLV 53
            ||  |..||:|.|.|.    :...||..:..| .|:|:.|:....||          |..:.|..
  Rat    17 GFFQGAFLLSLFLVLFKAVQFYLRRQWLLKAL-EKFPSTPSHWLWGHDLKDREFQQVLTWVEKFP 80

  Fly    54 GPHPLRRATEMINEHLHDHRAKLWM-GTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCE 117
            |                  ....|: |:|..::..:|..::.:..... .:.:..|:....|:..
  Rat    81 G------------------ACLQWLSGSKTRVLLYDPDYVKVVLGRSD-PKASGIYQFLAPWIVS 126

  Fly   118 G-----LFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLI 177
            |     |..:| :||....:::.|||:|.::|.:|.:......|:|....|..:....::....:
  Rat   127 GTGYGLLLLNG-KKWFQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYV 190

  Fly   178 SCFTLDTICETALG------VSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHY 236
            |..||||:.:.|..      :.|.|:|     |..||:.:..:...|:::.||.||.|:..:|..
  Rat   191 SLMTLDTVMKCAFSHQGSVQLDVNSRS-----YTKAVEDLNNLTFFRVRSAFYGNSIIYNMSSDG 250

  Fly   237 KREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPL 301
            :..:...:..|..|:|:|:.|..::..:.|.:..:.        ||.|.|||.||.:|..|||.|
  Rat   251 RLSRRACQIAHEHTDGVIKMRKAQLQNEEELQKARK--------KRHLDFLDILLFAKMEDGKSL 307

  Fly   302 TVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQL 366
            :.:|:|.||||.:|.|.|.||:.:::..|.:..|||||:||||||.|:.|...|  ::.:.:.|:
  Rat   308 SDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTS--VTWDHLDQI 370

  Fly   367 EFLEACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPD 430
            .:...||||.||:||..|..:|:.::..|..| ..||||....|....:.....::|:|.||.|.
  Rat   371 SYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRSIPKGITTTILIYGLHHNPSYWPNPKVFDPS 435

  Fly   431 RWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            |::..: |: .:..::||..|||:|:|:::||..||:.:|..|..|...|
  Rat   436 RFSPDS-PR-HSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	131/469 (28%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	127/452 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850