DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp312a1 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	167/546 - (30%)
Similarity:	264/546 - (48%)	Gaps:	82/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLGFG--------LLLLALSLYLL-------YVFER--QSRIDRLTHKWPAPPALP-FIGHLHIL 49
            |||..        ||||..:.:||       |:|.|  |...|     :|.||... |:|||.::
  Rat     8 WLGLRLETSLPWLLLLLIGASWLLVRVLTQTYIFYRTYQHLCD-----FPQPPKWNWFLGHLGMI 67

  Fly    50 ----------AKLVGPHPLRRATEMINEHLHDHRAKLWMGTKLYLVD-CNPKDIQAL--CSAQQL 101
                      .|||..:|....|              |:|..|.::. |:|..|:::  .||...
  Rat    68 TPTEQGLKQVTKLVATYPQGFMT--------------WLGPILPIITLCHPDVIRSVLSASASVA 118

  Fly   102 LQKTNDYRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAE 166
            |::...|...:.||.:||..|..:|||..|:::.|||::.::|.:|.:|...:.|:.......|.
  Rat   119 LKEVIFYSFLKPWLGDGLLLSDGDKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLAS 183

  Fly   167 SGD-QIDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIF 230
            .|. ::|..:.||..|||::.:.........|.. .|||:.|:..:..::.||.:.:......::
  Rat   184 GGSARLDMFKNISLMTLDSLQKCVFSFDSNCQEK-PSEYISAILELSALVAKRYQQLLLHTDSLY 247

  Fly   231 KRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVK-----RTLCFLDTL 290
            :.|.:.:|..:..|.:|.||:.:||.|          |....|..|.|.:|     :||.|:|.|
  Rat   248 QLTHNGRRFHKACKLVHNFTDAVIQGR----------RRALPSQHEDDILKAKARSKTLDFIDVL 302

  Fly   291 LLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKS 355
            ||:|..|||.|:.:|||.|.||.:|.|.|.||:.|::.:||:..|||:|:|||:||..:....:|
  Rat   303 LLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRES 367

  Fly   356 EPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKD 419
            ..|..:.:.||.||..||||:||::|...:.:|:.|.:..:.| ..||||...||:.........
  Rat   368 TEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPT 432

  Fly   420 FFPDPMVFKPDRWAIGAEPK----IEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            .:|||.|:.|.|:    :|:    .....||||.||.|:|:||.:||..:|:.||..|..|...|
  Rat   433 VWPDPEVYDPFRF----DPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLP 493

  Fly   481 LGERQVKLKLNFVITLH-----TVEP 501
             .:::.:.|...::...     .|||
  Rat   494 -DDKEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	153/497 (31%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	143/470 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348633
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750